Detailed information of TA system TA124949

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1907191..1907750
• Replicon: chromosome
• Accession: NZ_CP040100
• Organism: Vibrio parahaemolyticus strain LVP1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A347UR22
• Locus tag: FDP11_RS17400
• Protein ID: WP_005398411.1
• Coordinates: 1907472..1907750 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FDP11_RS17395
• Protein ID: WP_178982389.1
• Coordinates: 1907191..1907475 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDP11_RS17355	1903689..1903778	-	90	WP_080258923.1	DUF3265 domain-containing protein	-
FDP11_RS17360	1903796..1904338	-	543	WP_029863002.1	GNAT family N-acetyltransferase	-
FDP11_RS17365	1904371..1904514	-	144	WP_171345198.1	DUF3265 domain-containing protein	-
FDP11_RS17370	1904839..1905030	-	192	WP_178983104.1	DUF3265 domain-containing protein	-
FDP11_RS17375	1905546..1905920	-	375	WP_075111374.1	hypothetical protein	-
FDP11_RS17380	1906096..1906434	-	339	WP_178982385.1	hypothetical protein	-
FDP11_RS17385	1906693..1906998	-	306	WP_029801301.1	hypothetical protein	-
FDP11_RS17390	1906995..1907114	-	120	WP_178982387.1	DUF3265 domain-containing protein	-
FDP11_RS17395	1907191..1907475	+	285	WP_178982389.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FDP11_RS17400	1907472..1907750	+	279	WP_005398411.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FDP11_RS17405	1908368..1908877	-	510	WP_020840826.1	hypothetical protein	-
FDP11_RS17410	1908795..1908998	-	204	WP_178983106.1	DUF3265 domain-containing protein	-
FDP11_RS17415	1909020..1909238	-	219	WP_178982391.1	hypothetical protein	-
FDP11_RS17420	1909690..1909950	-	261	WP_178982393.1	hypothetical protein	-
FDP11_RS17425	1909978..1910091	-	114	WP_080931135.1	DUF3265 domain-containing protein	-
FDP11_RS17430	1910085..1910624	-	540	WP_005494855.1	hypothetical protein	-
FDP11_RS17435	1910658..1910804	-	147	WP_178983108.1	DUF3265 domain-containing protein	-
FDP11_RS17440	1910765..1911178	-	414	WP_178982395.1	hypothetical protein	-
FDP11_RS17445	1911321..1911719	-	399	WP_025527425.1	SMI1/KNR4 family protein	-
FDP11_RS17450	1911746..1911856	-	111	WP_079764959.1	DUF3265 domain-containing protein	-
FDP11_RS17455	1911881..1912174	-	294	WP_021823121.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	VP1611	1580898..1919556	338658
	-	inside	Integron	-	-	1843718..2009909	166191

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10891.57 Da
• Isoelectric Point: 4.3430

>T124949 WP_005398411.1 NZ_CP040100:1907472-1907750 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T124949 NZ_CP040100:1907472-1907750 [Vibrio parahaemolyticus]
ATGATTTTATGGGAAGAAGAATCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGATAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAAATTTCGATGATTGTATCTTACTGGGTTGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAGAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11072.42 Da
• Isoelectric Point: 8.0533

>AT124949 WP_178982389.1 NZ_CP040100:1907191-1907475 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGMQ

Nucleotide

• Length: 285 bp

>AT124949 NZ_CP040100:1907191-1907475 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTATGCAATGA

Structures

Toxin

• AlphaFold DB: A0A347UR22