Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1884052..1884599 | Replicon | chromosome |
| Accession | NZ_CP040100 | ||
| Organism | Vibrio parahaemolyticus strain LVP1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | FDP11_RS17180 | Protein ID | WP_178982360.1 |
| Coordinates | 1884052..1884354 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | FDP11_RS17185 | Protein ID | WP_005448240.1 |
| Coordinates | 1884342..1884599 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FDP11_RS17140 | 1879879..1880823 | - | 945 | WP_140329209.1 | D-2-hydroxyacid dehydrogenase family protein | - |
| FDP11_RS17145 | 1880978..1881424 | - | 447 | WP_178982358.1 | GNAT family N-acetyltransferase | - |
| FDP11_RS17150 | 1881560..1881913 | - | 354 | WP_053441516.1 | hypothetical protein | - |
| FDP11_RS17155 | 1881951..1882070 | - | 120 | WP_154218809.1 | DUF3265 domain-containing protein | - |
| FDP11_RS17160 | 1882067..1882411 | - | 345 | WP_178981683.1 | hypothetical protein | - |
| FDP11_RS17165 | 1882575..1882793 | - | 219 | WP_021485178.1 | hypothetical protein | - |
| FDP11_RS17170 | 1882916..1883071 | - | 156 | WP_079740745.1 | DUF3265 domain-containing protein | - |
| FDP11_RS17175 | 1883061..1883366 | - | 306 | WP_025787418.1 | hypothetical protein | - |
| FDP11_RS17180 | 1884052..1884354 | - | 303 | WP_178982360.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FDP11_RS17185 | 1884342..1884599 | - | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FDP11_RS17190 | 1884790..1885365 | - | 576 | WP_140110563.1 | hypothetical protein | - |
| FDP11_RS17195 | 1885521..1885787 | - | 267 | WP_176281179.1 | hypothetical protein | - |
| FDP11_RS17200 | 1885898..1886044 | - | 147 | WP_079725706.1 | DUF3265 domain-containing protein | - |
| FDP11_RS17205 | 1885980..1887116 | - | 1137 | WP_025769046.1 | DUF4238 domain-containing protein | - |
| FDP11_RS17210 | 1887868..1888203 | - | 336 | WP_178982362.1 | hypothetical protein | - |
| FDP11_RS17215 | 1888389..1888730 | - | 342 | WP_025502573.1 | hypothetical protein | - |
| FDP11_RS17220 | 1888706..1888873 | - | 168 | WP_155394336.1 | DUF3265 domain-containing protein | - |
| FDP11_RS17225 | 1888870..1889325 | - | 456 | WP_178982363.1 | GNAT family N-acetyltransferase | - |
| FDP11_RS17230 | 1889353..1889466 | - | 114 | WP_171842749.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | VP1611 | 1580898..1919556 | 338658 | |
| - | inside | Integron | - | - | 1843718..2009909 | 166191 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11554.44 Da Isoelectric Point: 5.1765
>T124948 WP_178982360.1 NZ_CP040100:c1884354-1884052 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENTVAAKQLVQAIFSKVERLEAFPESGRIPPELAHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENTVAAKQLVQAIFSKVERLEAFPESGRIPPELAHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T124948 NZ_CP040100:c1884354-1884052 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCTGACCTCAATGATATCGCTGAATATATCGCACTTGAAAATACCGT
AGCTGCAAAACAATTGGTTCAAGCGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCGC
CTGAACTGGCACATCTAAGTTATCGTGAAGTTGTAGTTAATCCGTGCCGTATTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGACTTACGTAAGTTCCTATTGAGTAAGCAATAA
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCTGACCTCAATGATATCGCTGAATATATCGCACTTGAAAATACCGT
AGCTGCAAAACAATTGGTTCAAGCGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCGC
CTGAACTGGCACATCTAAGTTATCGTGAAGTTGTAGTTAATCCGTGCCGTATTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGACTTACGTAAGTTCCTATTGAGTAAGCAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT124948 WP_005448240.1 NZ_CP040100:c1884599-1884342 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT124948 NZ_CP040100:c1884599-1884342 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGCTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCTGACGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
ATGAAAGTAGAACTAGTTACATCACTTAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGCTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCTGACGGTAAAGTGGTGAGTCACGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|