Detailed information of TA system TA124947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1846361..1846906
• Replicon: chromosome
• Accession: NZ_CP040100
• Organism: Vibrio parahaemolyticus strain LVP1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FDP11_RS16805
• Protein ID: WP_140329459.1
• Coordinates: 1846610..1846906 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FDP11_RS16800
• Protein ID: WP_023585842.1
• Coordinates: 1846361..1846603 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDP11_RS16775	1842657..1843511	+	855	WP_178982300.1	WYL domain-containing protein	-
FDP11_RS16780	1843718..1844443	-	726	WP_178982302.1	hypothetical protein	-
FDP11_RS16785	1844486..1844575	-	90	WP_069545109.1	DUF3265 domain-containing protein	-
FDP11_RS16790	1844969..1845058	-	90	WP_069545109.1	DUF3265 domain-containing protein	-
FDP11_RS16795	1846156..1846284	-	129	WP_178983087.1	DUF3265 domain-containing protein	-
FDP11_RS16800	1846361..1846603	+	243	WP_023585842.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FDP11_RS16805	1846610..1846906	+	297	WP_140329459.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FDP11_RS16810	1847076..1847435	-	360	Protein_1644	DUF2750 domain-containing protein	-
FDP11_RS16815	1847465..1847644	-	180	WP_178982304.1	DUF3265 domain-containing protein	-
FDP11_RS16820	1847584..1848108	-	525	WP_178982306.1	GNAT family N-acetyltransferase	-
FDP11_RS16825	1848289..1848579	-	291	WP_140276582.1	YkgJ family cysteine cluster protein	-
FDP11_RS16830	1848809..1849309	-	501	WP_178982308.1	hypothetical protein	-
FDP11_RS16835	1849467..1851107	-	1641	WP_178982310.1	RNA-directed DNA polymerase	-
FDP11_RS16840	1851146..1851223	-	78	WP_140329475.1	DUF3265 domain-containing protein	-
FDP11_RS16845	1851262..1851687	-	426	WP_140329472.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	VP1611	1580898..1919556	338658
	-	inside	Integron	-	-	1843718..2009909	166191

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-54)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11354.05 Da
• Isoelectric Point: 9.6270

>T124947 WP_140329459.1 NZ_CP040100:1846610-1846906 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLLKIKNYTVNNFSEMQWRNYKDTLLTGFQMLADNPEVGRSCYDIYPNGFHFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T124947 NZ_CP040100:1846610-1846906 [Vibrio parahaemolyticus]
ATGCAAAAGAATAAATACAAACTAAGTAAATTAGCTCAGGCTCATCTATTAAAAATCAAAAACTACACCGTTAATAACTT
TTCAGAGATGCAGTGGCGCAATTACAAAGATACGTTACTAACTGGGTTTCAGATGCTTGCTGACAATCCGGAGGTTGGTA
GAAGTTGCTATGACATTTACCCAAACGGGTTTCACTTTCCTGTTGGTAAGCACACAGCTTACTTTACAAAAGAAGACGGC
TTCATTTTGGTTGTAGCTGTACTCGGTCAGTCACAATTACCGCAAAACCACTTATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8917.15 Da
• Isoelectric Point: 5.1006

>AT124947 WP_023585842.1 NZ_CP040100:1846361-1846603 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKKDLAQGNVVDGEDFLSAL

Nucleotide

• Length: 243 bp

>AT124947 NZ_CP040100:1846361-1846603 [Vibrio parahaemolyticus]
ATGCACACATTAACAGCAAATGATGCGAAACGTAATTTTGGTGAACTTCTTCTGAGTGCCCAACGTGAGCCAGTAAAAAT
TAGCAAAAACAGTAAAGACGCCGTAGTTGTAATGTCTATTAAAGATTATGAAGAGCTAGAAGCTATGAAAGCTGATTACC
TTAAACATTGCTTTGAATCCGCGAAAAAAGACCTAGCGCAAGGCAATGTGGTTGATGGTGAAGACTTCTTGAGCGCCTTG
TAA