Detailed information of TA system TA124946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 3048490..3048927
• Replicon: chromosome
• Accession: NZ_CP040098
• Organism: Desulfoglaeba alkanexedens ALDC

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FDQ92_RS13780
• Protein ID: WP_211341284.1
• Coordinates: 3048769..3048927 (+)
• Length: 53 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FDQ92_RS13775
• Protein ID: WP_137425427.1
• Coordinates: 3048490..3048705 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDQ92_RS13755	3044734..3045756	+	1023	WP_137425423.1	rod shape-determining protein	-
FDQ92_RS13760	3045920..3046120	+	201	WP_137425424.1	hypothetical protein	-
FDQ92_RS13765	3046679..3047359	+	681	WP_137425425.1	CBS and ACT domain-containing protein	-
FDQ92_RS13770	3047403..3048002	+	600	WP_137425426.1	hypothetical protein	-
FDQ92_RS13775	3048490..3048705	+	216	WP_137425427.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FDQ92_RS13780	3048769..3048927	+	159	WP_211341284.1	type II toxin-antitoxin system HicA family toxin	Toxin
FDQ92_RS13785	3049247..3049636	+	390	WP_137425428.1	metallopeptidase family protein	-
FDQ92_RS13790	3050475..3052028	-	1554	WP_137425429.1	methylmalonyl-CoA carboxyltransferase	-
FDQ92_RS13795	3052158..3053648	-	1491	WP_137425430.1	sigma 54-interacting transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (1-41)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-55)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5873.88 Da
• Isoelectric Point: 9.5630

>T124946 WP_211341284.1 NZ_CP040098:3048769-3048927 [Desulfoglaeba alkanexedens ALDC]
VVRIKESHRFLRHADGRCTVAAVHRGDTIGPGLMSKILRHCDMTSDELVKFL

Nucleotide

• Length: 159 bp

>T124946 NZ_CP040098:3048769-3048927 [Desulfoglaeba alkanexedens ALDC]
GTGGTACGCATCAAGGAAAGTCATCGCTTTCTACGCCATGCTGACGGTCGGTGTACGGTTGCTGCCGTTCATCGTGGAGA
CACCATTGGTCCGGGGTTGATGTCTAAGATTCTGCGCCATTGCGACATGACCTCTGACGAGTTAGTGAAATTCCTGTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8157.46 Da
• Isoelectric Point: 4.7499

>AT124946 WP_137425427.1 NZ_CP040098:3048490-3048705 [Desulfoglaeba alkanexedens ALDC]
MAKAFNVIIERDSEGYYVATVPEFRGCHTQAKSLNVLMKRIREAIELYLEVEGEGISLPEFVGIQRIWVEL

Nucleotide

• Length: 216 bp

>AT124946 NZ_CP040098:3048490-3048705 [Desulfoglaeba alkanexedens ALDC]
ATGGCGAAAGCCTTTAACGTCATCATTGAACGTGATAGCGAAGGTTATTACGTTGCCACCGTGCCTGAATTCCGCGGCTG
TCACACGCAAGCCAAGTCGCTGAATGTTCTAATGAAACGTATTCGTGAGGCGATTGAGTTGTACTTGGAAGTTGAAGGCG
AAGGTATCTCACTCCCAGAATTTGTAGGGATTCAGCGCATCTGGGTTGAACTATGA