Detailed information of TA system TA124937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2719151..2719782
• Replicon: chromosome
• Accession: NZ_CP040095
• Organism: Pantoea sp. SO10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FCN45_RS12610
• Protein ID: WP_137386130.1
• Coordinates: 2719384..2719782 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FCN45_RS12605
• Protein ID: WP_101763423.1
• Coordinates: 2719151..2719384 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCN45_RS12600	2716008..2719079	+	3072	WP_137386129.1	multidrug efflux RND transporter permease subunit MdtC	-
FCN45_RS12605	2719151..2719384	+	234	WP_101763423.1	antitoxin	Antitoxin
FCN45_RS12610	2719384..2719782	+	399	WP_137386130.1	type II toxin-antitoxin system VapC family toxin	Toxin
FCN45_RS12615	2719799..2721205	+	1407	WP_137386131.1	multidrug transporter subunit MdtD	-
FCN45_RS12620	2721202..2722587	+	1386	WP_101763347.1	two-component system sensor histidine kinase BaeS	-
FCN45_RS12625	2722597..2723304	+	708	WP_101763346.1	two-component system response regulator BaeR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.33 Da
• Isoelectric Point: 8.0933

>T124937 WP_137386130.1 NZ_CP040095:2719384-2719782 [Pantoea sp. SO10]
MHRYMLDTNIVIYVIKRRPIEVLERFNANVGRMVISTITLAELFHGSEKSAFPERNLRIVEDFVSRLDVLNYDAKAAFHY
GAIRAELEKNGTPIGLNDLHIAAHARSAALTLVSNNLREFSRVNGLICENWI

Nucleotide

• Length: 399 bp

>T124937 NZ_CP040095:2719384-2719782 [Pantoea sp. SO10]
ATGCATCGCTACATGCTGGATACCAATATTGTTATCTACGTCATCAAGCGGCGGCCGATTGAGGTGCTCGAACGTTTCAA
CGCCAATGTCGGCCGGATGGTTATCTCGACGATCACCCTGGCGGAGTTGTTCCATGGCTCAGAAAAGAGCGCCTTTCCTG
AGCGGAACTTACGCATCGTTGAAGATTTTGTCTCACGCCTTGATGTGCTGAATTACGATGCCAAAGCCGCTTTCCATTAT
GGCGCTATCCGCGCAGAACTGGAGAAAAATGGCACGCCTATCGGCCTGAACGATCTTCATATCGCCGCTCATGCCCGCAG
TGCCGCCCTGACGTTGGTATCGAACAATTTGCGTGAATTTTCACGCGTGAATGGGCTGATCTGCGAAAACTGGATCTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8780.67 Da
• Isoelectric Point: 4.2683

>AT124937 WP_101763423.1 NZ_CP040095:2719151-2719384 [Pantoea sp. SO10]
MSQGTVFTSNRTQNVRIPADVRFPDDVKNVTVRAIGKERILTPIENAWDSFFLDGPTVSDDFMDERASQEQSEREAF

Nucleotide

• Length: 234 bp

>AT124937 NZ_CP040095:2719151-2719384 [Pantoea sp. SO10]
ATGTCACAAGGTACCGTGTTCACCAGCAACAGGACACAAAACGTTCGCATTCCAGCAGACGTTCGTTTTCCTGATGATGT
AAAAAACGTCACCGTCAGAGCAATCGGCAAGGAGCGCATCCTCACGCCCATAGAGAACGCCTGGGACAGTTTTTTCCTCG
ACGGTCCGACGGTGAGCGATGATTTTATGGATGAGCGTGCTTCGCAGGAACAATCTGAGCGGGAAGCGTTTTAA