Detailed information of TA system TA124936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2632233..2632852
• Replicon: chromosome
• Accession: NZ_CP040095
• Organism: Pantoea sp. SO10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: J3D643
• Locus tag: FCN45_RS12250
• Protein ID: WP_007891008.1
• Coordinates: 2632664..2632852 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FCN45_RS12245
• Protein ID: WP_101763410.1
• Coordinates: 2632233..2632646 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCN45_RS12225	2628160..2628987	-	828	WP_137386082.1	MetQ/NlpA family lipoprotein	-
FCN45_RS12230	2629202..2629843	+	642	WP_137386083.1	TetR family transcriptional regulator	-
FCN45_RS12235	2629918..2631300	+	1383	WP_137386084.1	FAD-binding protein	-
FCN45_RS12240	2631319..2632146	+	828	WP_137386085.1	glycosyltransferase family 8 protein	-
FCN45_RS12245	2632233..2632646	-	414	WP_101763410.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FCN45_RS12250	2632664..2632852	-	189	WP_007891008.1	type II toxin-antitoxin system HicA family toxin	Toxin
FCN45_RS12255	2632994..2633314	-	321	WP_008110563.1	DUF496 family protein	-
FCN45_RS12260	2633476..2634534	-	1059	WP_101763409.1	FUSC family protein	-
FCN45_RS12265	2634843..2636009	-	1167	WP_210421282.1	serine-type D-Ala-D-Ala carboxypeptidase DacD	-
FCN45_RS12270	2636212..2637633	+	1422	WP_101763407.1	exodeoxyribonuclease I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6984.25 Da
• Isoelectric Point: 11.0007

>T124936 WP_007891008.1 NZ_CP040095:c2632852-2632664 [Pantoea sp. SO10]
MDSRSLMAEIKADGWELIRVNGSHHHFVHPVKKGLVTIPHPKKDLPIKTVKSIRKQAGLTVH

Nucleotide

• Length: 189 bp

>T124936 NZ_CP040095:c2632852-2632664 [Pantoea sp. SO10]
ATGGATAGCAGATCATTAATGGCCGAGATCAAGGCCGATGGCTGGGAACTGATACGTGTAAACGGTAGCCATCACCATTT
TGTCCATCCGGTAAAAAAAGGGCTGGTGACGATACCGCACCCCAAAAAGGATTTGCCGATCAAAACGGTGAAAAGTATCA
GGAAACAAGCCGGACTGACTGTCCATTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14914.23 Da
• Isoelectric Point: 4.5951

>AT124936 WP_101763410.1 NZ_CP040095:c2632646-2632233 [Pantoea sp. SO10]
MFYPIAIEAGDQSTAFGVTVPDLPGCFSAGDTLEAAVTNAKEAIIGHLELLVELEQDIPAVSELKSLMKDPQYAGYVWVL
IDVDVTRILGGSEKINVTLPKLLIDRIDRCVATHPEFKTRSGFLAQVALERIAKTRS

Nucleotide

• Length: 414 bp

>AT124936 NZ_CP040095:c2632646-2632233 [Pantoea sp. SO10]
ATGTTTTATCCCATCGCGATTGAGGCGGGTGACCAAAGCACGGCATTTGGCGTCACGGTGCCGGATTTGCCGGGCTGTTT
TTCTGCTGGAGATACGCTGGAAGCGGCGGTAACAAATGCCAAAGAGGCGATTATCGGCCATCTGGAGCTGCTGGTAGAAT
TAGAGCAGGACATCCCGGCGGTTTCTGAATTGAAATCGTTGATGAAAGATCCGCAATATGCAGGTTATGTTTGGGTACTT
ATTGATGTGGATGTCACTCGCATTTTGGGCGGGTCCGAGAAAATCAACGTAACCTTGCCAAAACTGCTGATTGATCGCAT
TGACCGCTGCGTAGCAACGCATCCCGAATTCAAAACCCGTTCAGGTTTTTTGGCGCAGGTCGCGCTCGAGCGCATTGCGA
AGACCCGTTCATAA

Structures

Toxin

• AlphaFold DB: J3D643