Detailed information of TA system TA124935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 2622759..2623349
• Replicon: chromosome
• Accession: NZ_CP040095
• Organism: Pantoea sp. SO10

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: FCN45_RS12190
• Protein ID: WP_137386077.1
• Coordinates: 2622759..2623091 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: FCN45_RS12195
• Protein ID: WP_075808466.1
• Coordinates: 2623092..2623349 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCN45_RS12170	2617921..2618952	-	1032	WP_101763421.1	ABC transporter permease	-
FCN45_RS12175	2618967..2620451	-	1485	WP_101763420.1	sugar ABC transporter ATP-binding protein	-
FCN45_RS12180	2620485..2621408	-	924	WP_110866691.1	sugar ABC transporter substrate-binding protein	-
FCN45_RS12190	2622759..2623091	-	333	WP_137386077.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FCN45_RS12195	2623092..2623349	-	258	WP_075808466.1	antitoxin	Antitoxin
FCN45_RS12205	2623767..2625071	-	1305	WP_137386078.1	NtaA/DmoA family FMN-dependent monooxygenase	-
FCN45_RS12210	2625083..2626282	-	1200	WP_137386079.1	M20 family metallopeptidase	-
FCN45_RS12215	2626380..2627036	-	657	WP_137386080.1	ABC transporter permease	-
FCN45_RS12220	2627017..2628147	-	1131	WP_137386081.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-108)

Antitoxin

• Antitoxin PemI-like (4-84)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11798.56 Da
• Isoelectric Point: 9.1674

>T124935 WP_137386077.1 NZ_CP040095:c2623091-2622759 [Pantoea sp. SO10]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNTLTRLPVVVPVTSGGNYAREAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Nucleotide

• Length: 333 bp

>T124935 NZ_CP040095:c2623091-2622759 [Pantoea sp. SO10]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCCGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCATTTAACACGCTCACCCGGTTGCCCGTTGTTGTCCCTGTGACCAGCGGCGGAAACTATGCTCGCG
AAGCCGGTTTCACCGTTTCACTGGACGGGGCGGGAACAAAAACAACGGGCGTGATCCGCTGCGACCAGCCCAGAACCATT
GATATGGGAGCCCGAAATGGTAAGCGACTGGAGCGTATACCCGACGCTGTCGTGAATGAGGTGCTGGCTCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9414.97 Da
• Isoelectric Point: 4.4620

>AT124935 WP_075808466.1 NZ_CP040095:c2623349-2623092 [Pantoea sp. SO10]
MYTTRLKKVGGSIMLAVPPAVLKTLELSMGSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Nucleotide

• Length: 258 bp

>AT124935 NZ_CP040095:c2623349-2623092 [Pantoea sp. SO10]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCCCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGATGGGCAGCGAAGTGGGTATGACTATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGTTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGTGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA