Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1077476..1078096 Replicon chromosome
Accession NZ_CP040095
Organism Pantoea sp. SO10

Toxin (Protein)


Gene name Hha Uniprot ID J2UI73
Locus tag FCN45_RS04905 Protein ID WP_007886938.1
Coordinates 1077476..1077694 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J3DFW0
Locus tag FCN45_RS04910 Protein ID WP_007886936.1
Coordinates 1077719..1078096 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCN45_RS04875 1073219..1073557 + 339 WP_007886947.1 P-II family nitrogen regulator -
FCN45_RS04880 1073591..1074880 + 1290 WP_101762414.1 ammonium transporter AmtB -
FCN45_RS04885 1074953..1075816 - 864 WP_101762413.1 acyl-CoA thioesterase II -
FCN45_RS04890 1076022..1076579 + 558 WP_110867736.1 YbaY family lipoprotein -
FCN45_RS04895 1076761..1077072 - 312 WP_008103902.1 MGMT family protein -
FCN45_RS04905 1077476..1077694 - 219 WP_007886938.1 hemolysin expression modulator Hha Toxin
FCN45_RS04910 1077719..1078096 - 378 WP_007886936.1 Hha toxicity modulator TomB Antitoxin
FCN45_RS04915 1078245..1078598 - 354 WP_137385282.1 hypothetical protein -
FCN45_RS04920 1078939..1079595 + 657 WP_137385283.1 ABC transporter ATP-binding protein -
FCN45_RS04925 1079592..1080431 + 840 WP_137385284.1 metal ABC transporter permease -
FCN45_RS04930 1080454..1081332 + 879 WP_110867733.1 metal ABC transporter substrate-binding protein -
FCN45_RS04935 1081377..1081517 - 141 WP_137385285.1 type B 50S ribosomal protein L36 -
FCN45_RS04940 1081533..1081790 - 258 WP_101762406.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8594.98 Da        Isoelectric Point: 9.5023

>T124932 WP_007886938.1 NZ_CP040095:c1077694-1077476 [Pantoea sp. SO10]
MSNQALTKTDYLMRLRRCRSIDTLERVIEKNKYELPDNELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 219 bp

>T124932 NZ_CP040095:c1077694-1077476 [Pantoea sp. SO10]
ATGAGCAACCAAGCCTTAACTAAAACAGATTATTTGATGCGACTGCGCCGCTGTCGCTCAATCGATACCCTTGAACGGGT
TATCGAAAAAAACAAGTATGAATTACCTGATAATGAACTCGCGGTATTCTATTCGGCAGCCGATCATCGTCTGGCTGAAC
TGACAATGAATAAGCTTTACGATAAAGTACCGGTTTCTGTCTGGAAGTTCGTCCGCTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14743.36 Da        Isoelectric Point: 4.4069

>AT124932 WP_007886936.1 NZ_CP040095:c1078096-1077719 [Pantoea sp. SO10]
MDEYSPKRHDIAQLKYLCENLFDESMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSSYGINTQDLQRWQRSAKRLFNLFAEECAYLQQPSHSF

Download         Length: 378 bp

>AT124932 NZ_CP040095:c1078096-1077719 [Pantoea sp. SO10]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACCTGTGTGAGAACCTGTTCGACGAAAGTATGGC
GACATTGACCGACAGCCATCATGGTTGGGTTAATGATCCTACTTCGGAAAGCAATTTACAGCTCAACGATTTGATTGAGC
ATATCGCTTCTTTCACGATGAATTACAAAATTAAGCACGTTGAAGATGAAGCCCTGATTACGCAAATCGATGAATATCTT
GACGATACCTTTATGCTGTTCAGCAGCTATGGAATCAATACTCAGGATCTACAACGGTGGCAGCGTTCAGCAAAACGCTT
ATTTAATCTGTTTGCCGAAGAGTGCGCTTATCTCCAACAACCTAGCCATTCCTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2M9WAL0

Antitoxin

Source ID Structure
AlphaFold DB J3DFW0

References