Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 6612123..6612682 Replicon chromosome
Accession NZ_CP040094
Organism Nostoc sp. TCL240-02

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FBB35_RS28220 Protein ID WP_174712393.1
Coordinates 6612123..6612461 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FBB35_RS28225 Protein ID WP_174712394.1
Coordinates 6612458..6612682 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBB35_RS28190 6607431..6608261 - 831 WP_174712388.1 PD-(D/E)XK nuclease family protein -
FBB35_RS28195 6608579..6608782 - 204 WP_094330501.1 hypothetical protein -
FBB35_RS28200 6608793..6609356 - 564 WP_174712389.1 peptide deformylase -
FBB35_RS28205 6609515..6610417 + 903 WP_174712390.1 ABC transporter permease -
FBB35_RS28210 6610490..6611347 + 858 WP_174712391.1 DUF3598 family protein -
FBB35_RS28215 6611469..6612041 + 573 WP_174712392.1 Uma2 family endonuclease -
FBB35_RS28220 6612123..6612461 - 339 WP_174712393.1 DUF5615 family PIN-like protein Toxin
FBB35_RS28225 6612458..6612682 - 225 WP_174712394.1 DUF433 domain-containing protein Antitoxin
FBB35_RS28230 6612892..6613836 - 945 WP_174712395.1 toll/interleukin-1 receptor domain-containing protein -
FBB35_RS28235 6614003..6614578 - 576 WP_174712396.1 leucyl/phenylalanyl-tRNA--protein transferase -
FBB35_RS28240 6614681..6615010 + 330 WP_114081874.1 hypothetical protein -
FBB35_RS28245 6615172..6615474 - 303 WP_012410383.1 30S ribosomal protein S14 -
FBB35_RS28250 6615551..6616240 - 690 WP_174712397.1 endonuclease III -
FBB35_RS28255 6616216..6617316 - 1101 WP_174712398.1 RIP metalloprotease RseP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-78)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12470.26 Da        Isoelectric Point: 4.3216

>T124929 WP_174712393.1 NZ_CP040094:c6612461-6612123 [Nostoc sp. TCL240-02]
MTIWVDAHLSPAIATWITITFGITALALRDVGLRDAEDPEIFEAARAREVIFMTKDSDFADLVDRFGSPPQVIWLTCGNT
SNARLKEILNSTLPEALELLRSGEALVEIRRD

Download         Length: 339 bp

>T124929 NZ_CP040094:c6612461-6612123 [Nostoc sp. TCL240-02]
ATGACAATCTGGGTAGATGCACATCTGTCACCTGCAATTGCAACTTGGATCACCATCACATTCGGCATAACGGCATTAGC
TTTGCGTGATGTTGGGCTGAGAGATGCCGAAGATCCTGAGATTTTTGAGGCAGCGAGGGCTAGAGAAGTTATTTTTATGA
CCAAAGACAGTGACTTTGCTGACTTGGTTGATCGTTTTGGAAGTCCACCACAAGTTATCTGGTTGACGTGTGGTAATACG
TCAAATGCACGATTGAAAGAGATTCTGAATTCAACATTGCCAGAAGCATTAGAGCTTTTGCGATCTGGTGAAGCGTTAGT
CGAAATCAGAAGGGATTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8062.44 Da        Isoelectric Point: 5.7582

>AT124929 WP_174712394.1 NZ_CP040094:c6612682-6612458 [Nostoc sp. TCL240-02]
MSDLLGRITVNPKQCGGRPCIRGMRIRVSDVLDLFAAGLSAEQILEEMPDLEADDLKAALVYASRKLNHPVLVA

Download         Length: 225 bp

>AT124929 NZ_CP040094:c6612682-6612458 [Nostoc sp. TCL240-02]
ATGTCAGACTTACTTGGAAGAATTACAGTTAATCCTAAACAATGTGGTGGTCGTCCCTGTATCAGAGGCATGAGAATTCG
GGTATCAGACGTACTCGACTTGTTTGCGGCAGGACTGAGTGCCGAACAAATCCTAGAAGAAATGCCCGATCTGGAAGCGG
ATGATCTTAAAGCAGCACTTGTGTACGCTTCACGTAAGCTCAATCATCCCGTTTTGGTTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References