Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6021217..6021812 Replicon chromosome
Accession NZ_CP040094
Organism Nostoc sp. TCL240-02

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FBB35_RS25680 Protein ID WP_174711983.1
Coordinates 6021217..6021477 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FBB35_RS25685 Protein ID WP_174711984.1
Coordinates 6021474..6021812 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBB35_RS25650 6018356..6019504 + 1149 WP_174711978.1 toll/interleukin-1 receptor domain-containing protein -
FBB35_RS25655 6019702..6019878 - 177 WP_174711979.1 hypothetical protein -
FBB35_RS25660 6019919..6020116 + 198 WP_174713766.1 hypothetical protein -
FBB35_RS25665 6020100..6020390 + 291 WP_174711980.1 type II toxin-antitoxin system PemK/MazF family toxin -
FBB35_RS25670 6020496..6020720 + 225 WP_174711981.1 addiction module protein -
FBB35_RS25675 6020717..6021013 + 297 WP_174711982.1 type II toxin-antitoxin system RelE/ParE family toxin -
FBB35_RS25680 6021217..6021477 + 261 WP_174711983.1 type II toxin-antitoxin system HicA family toxin Toxin
FBB35_RS25685 6021474..6021812 + 339 WP_174711984.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FBB35_RS25690 6021896..6022471 + 576 Protein_5023 Uma2 family endonuclease -
FBB35_RS25695 6023008..6023955 + 948 WP_174711985.1 GDP-mannose 4,6-dehydratase -
FBB35_RS25700 6024479..6025273 - 795 WP_174711986.1 molybdate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-84)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9722.23 Da        Isoelectric Point: 8.7566

>T124928 WP_174711983.1 NZ_CP040094:6021217-6021477 [Nostoc sp. TCL240-02]
MDLNNKQRQILELIFTNPVPSNILWKDIESLFIALGADITQGRGSRVRVKLNDVKAVFHEPHPQNETDKGAVKSVREFLI
KAGIEI

Download         Length: 261 bp

>T124928 NZ_CP040094:6021217-6021477 [Nostoc sp. TCL240-02]
ATGGATCTCAATAACAAACAACGTCAGATTTTAGAGTTGATTTTTACAAATCCTGTACCATCTAATATTCTTTGGAAAGA
TATTGAAAGTTTATTTATAGCTCTTGGTGCTGATATTACTCAAGGTAGAGGTTCGCGGGTTCGTGTGAAATTAAATGATG
TGAAAGCTGTTTTTCACGAACCGCATCCTCAAAATGAGACAGATAAAGGAGCAGTCAAATCTGTTAGAGAATTTTTAATT
AAGGCAGGAATTGAAATATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12526.27 Da        Isoelectric Point: 4.6051

>AT124928 WP_174711984.1 NZ_CP040094:6021474-6021812 [Nostoc sp. TCL240-02]
MITYKGYTASIEVDVEAGILFGQVLDINDVITFKAKTVEEARQEFQISVDDYLAFCEELGEEPDKPFSGKLPFRTTPEHH
RKIFIAAKKAGKSINAWMDEILTGAADKVINT

Download         Length: 339 bp

>AT124928 NZ_CP040094:6021474-6021812 [Nostoc sp. TCL240-02]
ATGATCACTTATAAGGGATACACAGCTAGTATAGAAGTAGATGTAGAAGCGGGAATACTTTTTGGCCAAGTTCTAGATAT
TAATGACGTAATTACCTTTAAGGCAAAAACTGTAGAGGAAGCGCGTCAAGAATTTCAAATTTCTGTTGATGATTATCTTG
CTTTCTGTGAAGAACTAGGAGAGGAGCCTGATAAACCATTCTCTGGTAAACTTCCATTCCGCACAACTCCAGAACACCAC
CGCAAAATATTTATTGCTGCTAAAAAGGCTGGCAAAAGCATAAATGCTTGGATGGATGAAATCTTAACTGGTGCTGCGGA
TAAAGTAATCAATACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References