Detailed information of TA system TA124926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 3185153..3185729
• Replicon: chromosome
• Accession: NZ_CP040094
• Organism: Nostoc sp. TCL240-02

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FBB35_RS13555
• Protein ID: WP_174710054.1
• Coordinates: 3185370..3185729 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FBB35_RS13550
• Protein ID: WP_174710053.1
• Coordinates: 3185153..3185383 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FBB35_RS13535	3181128..3183578	+	2451	WP_174710050.1	phenylalanine--tRNA ligase subunit beta	-
FBB35_RS13540	3183677..3183946	+	270	WP_174710051.1	YciI family protein	-
FBB35_RS13545	3184172..3184966	+	795	WP_174710052.1	Tab2/Atab2 family RNA-binding protein	-
FBB35_RS13550	3185153..3185383	+	231	WP_174710053.1	CopG family transcriptional regulator	Antitoxin
FBB35_RS13555	3185370..3185729	+	360	WP_174710054.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FBB35_RS13560	3185949..3187148	-	1200	WP_174710055.1	DUF4159 domain-containing protein	-
FBB35_RS13565	3187396..3188424	-	1029	WP_174710056.1	phage tail protein	-
FBB35_RS13570	3188498..3190696	-	2199	WP_174710057.1	putative baseplate assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (9-114)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13165.24 Da
• Isoelectric Point: 6.4543

>T124926 WP_174710054.1 NZ_CP040094:3185370-3185729 [Nostoc sp. TCL240-02]
MPGSSLTYQRGEIRWVNLDPTVGAEAKKIRACLIVQNDIMNQYGLLTIVMPFRPGSKQAPYVVNVKATPNNGLDQDSFID
IGQIRAVDHSRILGLVGVLESEYWELIHTALNVVLGFVV

Nucleotide

• Length: 360 bp

>T124926 NZ_CP040094:3185370-3185729 [Nostoc sp. TCL240-02]
ATGCCAGGGAGTAGTTTAACTTATCAGCGAGGAGAAATACGTTGGGTTAATCTTGATCCAACAGTGGGGGCTGAAGCGAA
AAAAATCCGCGCTTGCTTGATTGTGCAAAATGACATCATGAATCAGTATGGATTGCTGACAATTGTGATGCCATTTCGAC
CCGGAAGTAAACAAGCGCCCTACGTTGTAAATGTGAAAGCAACACCAAATAATGGACTAGACCAAGACAGTTTTATAGAT
ATTGGCCAAATTCGTGCTGTTGATCATAGTCGTATTTTGGGTTTGGTAGGTGTGCTGGAGTCAGAGTACTGGGAACTTAT
TCATACAGCTTTAAATGTAGTTCTGGGATTTGTAGTTTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8593.64 Da
• Isoelectric Point: 4.1677

>AT124926 WP_174710053.1 NZ_CP040094:3185153-3185383 [Nostoc sp. TCL240-02]
MLKVTITLEEDILQFVDQYAQGNRSAYINTLLAEHRRRILAAEMIAALKQDAEDPEYQTEIAAWDSVVGDGINARE

Nucleotide

• Length: 231 bp

>AT124926 NZ_CP040094:3185153-3185383 [Nostoc sp. TCL240-02]
ATGCTCAAAGTTACAATTACCTTAGAAGAAGATATTCTGCAATTTGTAGATCAGTATGCACAGGGAAATCGTAGTGCATA
CATCAATACACTGCTAGCAGAACACCGCCGCCGAATTTTAGCAGCAGAAATGATTGCAGCCCTCAAGCAGGATGCTGAAG
ATCCAGAATATCAAACTGAAATTGCTGCTTGGGATAGTGTTGTTGGGGATGGCATAAATGCCAGGGAGTAG