Detailed information of TA system TA124917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3054669..3055374
• Replicon: chromosome
• Accession: NZ_CP040090
• Organism: Escherichia coli strain FT130

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: FC325_RS14705
• Protein ID: WP_000539521.1
• Coordinates: 3054669..3055055 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FC325_RS14710
• Protein ID: WP_001280945.1
• Coordinates: 3055045..3055374 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FC325_RS14685	3050673..3051299	+	627	WP_089622771.1	glutathione S-transferase GstB	-
FC325_RS14690	3051296..3052411	-	1116	WP_000554946.1	aldose sugar dehydrogenase YliI	-
FC325_RS14695	3052522..3052905	-	384	WP_000497137.1	biofilm formation regulator BssR	-
FC325_RS14700	3053118..3054443	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
FC325_RS14705	3054669..3055055	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FC325_RS14710	3055045..3055374	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
FC325_RS14715	3055444..3056772	-	1329	WP_000086877.1	GGDEF domain-containing protein	-
FC325_RS14720	3056780..3059127	-	2348	Protein_2879	CHASE9 sensor domain-containing protein	-
FC325_RS14725	3059305..3060216	-	912	WP_001236044.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T124917 WP_000539521.1 NZ_CP040090:3054669-3055055 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T124917 NZ_CP040090:3054669-3055055 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT124917 WP_001280945.1 NZ_CP040090:3055045-3055374 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT124917 NZ_CP040090:3055045-3055374 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCATTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A829GCT6