Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2425227..2425865 Replicon chromosome
Accession NZ_CP040090
Organism Escherichia coli strain FT130

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag FC325_RS11630 Protein ID WP_000813794.1
Coordinates 2425689..2425865 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FC325_RS11625 Protein ID WP_001270286.1
Coordinates 2425227..2425643 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC325_RS11605 2420379..2421320 - 942 WP_001251313.1 ABC transporter permease -
FC325_RS11610 2421321..2422334 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
FC325_RS11615 2422352..2423497 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
FC325_RS11620 2423742..2425148 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
FC325_RS11625 2425227..2425643 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
FC325_RS11630 2425689..2425865 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
FC325_RS11635 2426087..2426317 + 231 WP_000494244.1 YncJ family protein -
FC325_RS11640 2426409..2428370 - 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
FC325_RS11645 2428443..2428979 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
FC325_RS11650 2429032..2430246 + 1215 WP_178970000.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T124916 WP_000813794.1 NZ_CP040090:c2425865-2425689 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T124916 NZ_CP040090:c2425865-2425689 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT124916 WP_001270286.1 NZ_CP040090:c2425643-2425227 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT124916 NZ_CP040090:c2425643-2425227 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References