Detailed information of TA system TA124903

Bioinformatically predicted

Overview

TA module

• Type: V
• Classification (family/domain): ghoTS/ghoT-GhoS
• Location: 791270..791723
• Replicon: chromosome
• Accession: NZ_CP040090
• Organism: Escherichia coli strain FT130

Toxin (Protein)

• Gene name: ghoT
• Uniprot ID: -
• Locus tag: FC325_RS03785
• Protein ID: WP_113441661.1
• Coordinates: 791610..791723 (+)
• Length: 38 a.a.

Antitoxin (Protein)

• Gene name: ghoS
• Uniprot ID: -
• Locus tag: FC325_RS03780
• Protein ID: WP_113441660.1
• Coordinates: 791270..791566 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FC325_RS03770	788350..790344	+	1995	Protein_739	DUF4092 domain-containing protein	-
FC325_RS03775	790342..790922	-	581	Protein_740	transposase	-
FC325_RS03780	791270..791566	+	297	WP_113441660.1	type V toxin-antitoxin system endoribonuclease antitoxin GhoS	Antitoxin
FC325_RS03785	791610..791723	+	114	WP_113441661.1	GhoT/OrtT family toxin	Toxin
FC325_RS03790	792486..792781	+	296	Protein_743	helix-turn-helix domain-containing protein	-
FC325_RS03800	794123..794350	+	228	WP_113441665.1	transposase	-
FC325_RS03805	794554..795105	+	552	WP_113441663.1	DDE-type integrase/transposase/recombinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	791270..801632	10362
	-	inside	IScluster/Tn	-	-	790512..794091	3579

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (10-37)

Antitoxin

• Endoribonuclease antitoxin GhoS (7-93)

Sequences

Toxin

Protein

• Length: 38 a.a.
• Molecular weight: 4123.13 Da
• Isoelectric Point: 8.5437

>T124903 WP_113441661.1 NZ_CP040090:791610-791723 [Escherichia coli]
MLCFYVFCGNIKIRLLSIFLVGITGPISLPVSLLFSF

Nucleotide

• Length: 114 bp

>T124903 NZ_CP040090:791610-791723 [Escherichia coli]
ATGTTGTGTTTTTATGTTTTTTGTGGCAATATCAAAATTCGTTTGCTTAGCATCTTCCTGGTTGGAATAACCGGTCCAAT
AAGTCTCCCTGTATCGTTACTCTTTTCTTTTTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11494.31 Da
• Isoelectric Point: 3.9615

>AT124903 WP_113441660.1 NZ_CP040090:791270-791566 [Escherichia coli]
MESKNSFDTYIISFDYPLSYFPFFLELKSLMHDMNFASIVIDKNGMLRELDINTLAITTLLVESEIEDLIMSMFSDLSDI
EFGLSVMKIDDYFCRIYK

Nucleotide

• Length: 297 bp

>AT124903 NZ_CP040090:791270-791566 [Escherichia coli]
ATGGAAAGTAAAAATAGCTTTGATACTTATATTATTTCTTTTGATTATCCATTATCGTATTTTCCGTTTTTCCTAGAGTT
AAAATCGTTAATGCATGATATGAATTTTGCATCTATAGTTATTGATAAAAATGGAATGCTGAGAGAATTGGATATAAATA
CTCTTGCAATAACTACATTACTGGTTGAAAGTGAAATTGAAGATTTAATCATGAGTATGTTTTCAGATCTGTCAGATATT
GAGTTTGGACTCAGTGTTATGAAGATTGATGACTATTTTTGTAGAATATATAAATAG