Detailed information of TA system TA124899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1076241..1076920
• Replicon: chromosome
• Accession: NZ_CP040087
• Organism: Acinetobacter baumannii strain VB35575

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FDN01_RS05130
• Protein ID: WP_000838146.1
• Coordinates: 1076241..1076423 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FDN01_RS05135
• Protein ID: WP_000966688.1
• Coordinates: 1076516..1076920 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDN01_RS19625	1071459..1071629	+	171	WP_000220307.1	hypothetical protein	-
FDN01_RS05090	1071640..1072050	+	411	WP_005135681.1	hypothetical protein	-
FDN01_RS05095	1072022..1072390	+	369	WP_114673977.1	HK97 gp10 family phage protein	-
FDN01_RS05100	1072392..1072790	+	399	WP_000178914.1	hypothetical protein	-
FDN01_RS05105	1072859..1073212	+	354	WP_017725146.1	hypothetical protein	-
FDN01_RS05110	1073212..1074360	+	1149	WP_114673978.1	phage tail protein	-
FDN01_RS05115	1074413..1075330	+	918	WP_114673979.1	hypothetical protein	-
FDN01_RS05120	1075400..1075915	+	516	WP_001185592.1	hypothetical protein	-
FDN01_RS05130	1076241..1076423	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FDN01_RS05135	1076516..1076920	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FDN01_RS05140	1077019..1077339	+	321	WP_000721573.1	hypothetical protein	-
FDN01_RS05145	1077442..1078185	+	744	WP_000599539.1	hypothetical protein	-
FDN01_RS05150	1078199..1078579	-	381	WP_000083174.1	hypothetical protein	-
FDN01_RS05155	1078722..1079669	+	948	WP_000096292.1	hypothetical protein	-
FDN01_RS05160	1079998..1080345	+	348	WP_099973747.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1045960..1094158	48198

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T124899 WP_000838146.1 NZ_CP040087:1076241-1076423 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T124899 NZ_CP040087:1076241-1076423 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT124899 WP_000966688.1 NZ_CP040087:1076516-1076920 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT124899 NZ_CP040087:1076516-1076920 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6