Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3060312..3060963 Replicon chromosome
Accession NZ_CP040084
Organism Acinetobacter baumannii strain VB33071

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag FDN00_RS14760 Protein ID WP_000838146.1
Coordinates 3060781..3060963 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag FDN00_RS14755 Protein ID WP_000966689.1
Coordinates 3060312..3060716 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDN00_RS14745 3055633..3059601 - 3969 WP_000191303.1 tape measure protein -
FDN00_RS14750 3059698..3060216 - 519 WP_126784048.1 DUF4468 domain-containing protein -
FDN00_RS14755 3060312..3060716 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FDN00_RS14760 3060781..3060963 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
FDN00_RS14765 3061295..3061828 - 534 WP_001185622.1 hypothetical protein -
FDN00_RS14770 3061873..3062802 - 930 WP_000094300.1 hypothetical protein -
FDN00_RS14775 3062911..3063123 - 213 WP_000121166.1 hypothetical protein -
FDN00_RS14780 3063125..3063523 - 399 WP_001132270.1 hypothetical protein -
FDN00_RS14785 3063525..3063893 - 369 WP_000539752.1 hypothetical protein -
FDN00_RS14790 3063865..3064269 - 405 WP_000248324.1 hypothetical protein -
FDN00_RS14795 3064278..3064646 - 369 WP_000524231.1 hypothetical protein -
FDN00_RS14800 3064648..3065037 - 390 WP_032041498.1 hypothetical protein -
FDN00_RS14805 3065042..3065707 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3040386..3089827 49441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T124895 WP_000838146.1 NZ_CP040084:c3060963-3060781 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T124895 NZ_CP040084:c3060963-3060781 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT124895 WP_000966689.1 NZ_CP040084:c3060716-3060312 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT124895 NZ_CP040084:c3060716-3060312 [Acinetobacter baumannii]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References