Detailed information of TA system TA124889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3332599..3333133
• Replicon: chromosome
• Accession: NZ_CP040078
• Organism: Burkholderia sp. DHOD12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FAZ95_RS37070
• Protein ID: WP_137337268.1
• Coordinates: 3332599..3332898 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FAZ95_RS37075
• Protein ID: WP_137337269.1
• Coordinates: 3332888..3333133 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FAZ95_RS37035	3328919..3329365	-	447	WP_137337264.1	hypothetical protein	-
FAZ95_RS37040	3329579..3330370	-	792	WP_137337792.1	hypothetical protein	-
FAZ95_RS37045	3330454..3330789	-	336	WP_137337265.1	hypothetical protein	-
FAZ95_RS37055	3331339..3331587	-	249	WP_137337266.1	hypothetical protein	-
FAZ95_RS37065	3332213..3332554	-	342	WP_137337267.1	hypothetical protein	-
FAZ95_RS37070	3332599..3332898	-	300	WP_137337268.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FAZ95_RS37075	3332888..3333133	-	246	WP_137337269.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FAZ95_RS37080	3333409..3334329	-	921	WP_137337270.1	hypothetical protein	-
FAZ95_RS37085	3334909..3335073	+	165	WP_137337793.1	PAAR domain-containing protein	-
FAZ95_RS37090	3335148..3336239	-	1092	WP_137337794.1	hypothetical protein	-
FAZ95_RS37095	3336324..3337223	-	900	WP_137337795.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3332213..3353180	20967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11730.41 Da
• Isoelectric Point: 7.8261

>T124889 WP_137337268.1 NZ_CP040078:c3332898-3332599 [Burkholderia sp. DHOD12]
MAAKGRQLRLTPLAERDLEDIWRFTFEHWSLDQANRYHRDLIATLEALARGDKIGCVCTVRDGYCRYAVGSHVVFYRETD
RTLDIIRILHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T124889 NZ_CP040078:c3332898-3332599 [Burkholderia sp. DHOD12]
ATGGCGGCTAAGGGGCGGCAGCTCCGGCTGACGCCGCTGGCCGAGCGCGACCTCGAGGATATCTGGCGCTTTACGTTTGA
GCACTGGTCGCTGGATCAGGCCAATCGCTATCACCGCGACCTGATTGCGACGCTCGAGGCGCTGGCGCGGGGTGACAAGA
TTGGTTGCGTCTGCACCGTGCGCGATGGGTATTGTCGGTATGCGGTCGGCTCGCACGTGGTGTTTTATCGGGAGACGGAT
CGGACGCTCGACATCATCCGGATCCTGCACCAGCGAATGGACGTCGACCGTCACCTGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8638.57 Da
• Isoelectric Point: 5.6423

>AT124889 WP_137337269.1 NZ_CP040078:c3333133-3332888 [Burkholderia sp. DHOD12]
MSRNTSVSLGEHFTEFIDAQVQTGRYGSASDVVRAGLRLLESQETQVRALQEALKAGEASGAPAPFDSEAFLARMRATHG
G

Nucleotide

• Length: 246 bp

>AT124889 NZ_CP040078:c3333133-3332888 [Burkholderia sp. DHOD12]
ATGTCACGCAACACATCCGTTTCGCTCGGCGAGCATTTCACCGAATTCATTGATGCGCAGGTCCAAACCGGACGGTATGG
TTCGGCGAGCGACGTCGTGCGGGCCGGCCTGCGTCTTCTTGAATCGCAGGAAACTCAAGTGCGTGCCTTGCAGGAGGCGC
TGAAGGCCGGCGAGGCGTCGGGCGCGCCCGCGCCGTTCGACAGCGAGGCTTTCCTGGCTCGGATGCGGGCGACGCATGGC
GGCTAA