Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2060916..2061493 Replicon chromosome
Accession NZ_CP040078
Organism Burkholderia sp. DHOD12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FAZ95_RS31390 Protein ID WP_137336316.1
Coordinates 2060916..2061281 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FAZ95_RS31395 Protein ID WP_137336317.1
Coordinates 2061275..2061493 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAZ95_RS31370 2056287..2057264 - 978 WP_137336313.1 hypothetical protein -
FAZ95_RS31375 2057733..2059103 + 1371 WP_137336314.1 MHS family MFS transporter -
FAZ95_RS31380 2059164..2059649 - 486 WP_137336315.1 YbaK/EbsC family protein -
FAZ95_RS31385 2059855..2060823 - 969 WP_137337692.1 LacI family DNA-binding transcriptional regulator -
FAZ95_RS31390 2060916..2061281 - 366 WP_137336316.1 type II toxin-antitoxin system VapC family toxin Toxin
FAZ95_RS31395 2061275..2061493 - 219 WP_137336317.1 ribbon-helix-helix protein, CopG family Antitoxin
FAZ95_RS31400 2061726..2063273 + 1548 WP_137336318.1 altronate dehydratase family protein -
FAZ95_RS31405 2063368..2064711 + 1344 WP_137336319.1 MFS transporter -
FAZ95_RS31410 2064698..2065474 + 777 WP_137336320.1 4-hydroxy-2-oxoheptanedioate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13457.59 Da        Isoelectric Point: 9.5595

>T124888 WP_137336316.1 NZ_CP040078:c2061281-2060916 [Burkholderia sp. DHOD12]
MVKALFDTNILIDYLGGIGAAQKELSRYESRAISTITWMEVLVGATAKEERAIRLWLNSFDVIALDSAIANRAVAIRKEK
RIRLPDAIVWASAQVNSLLLVSRNTKDFPADEPGVRVPYNV

Download         Length: 366 bp

>T124888 NZ_CP040078:c2061281-2060916 [Burkholderia sp. DHOD12]
ATGGTAAAAGCCCTTTTTGACACGAACATCCTGATCGATTATCTCGGCGGCATCGGCGCGGCCCAGAAAGAGCTGTCGCG
CTATGAGTCTCGAGCAATCAGCACGATCACGTGGATGGAAGTTCTGGTTGGCGCCACAGCGAAGGAAGAGAGGGCGATCC
GCTTATGGCTGAACTCGTTTGACGTCATCGCCTTGGACAGCGCGATCGCGAATCGCGCTGTCGCGATTCGCAAAGAGAAA
AGGATTCGCCTGCCCGACGCGATTGTCTGGGCCTCCGCGCAAGTGAATTCGCTGTTGCTCGTTTCGCGCAATACGAAGGA
TTTTCCGGCGGATGAGCCGGGTGTGCGTGTGCCCTACAACGTTTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8264.45 Da        Isoelectric Point: 5.0916

>AT124888 WP_137336317.1 NZ_CP040078:c2061493-2061275 [Burkholderia sp. DHOD12]
MSRVLVDIPDTQLEALAAIVEEEQRPRAALIRDAIEAYIADHKRLRGADVFGLWKSKKIDGLEYQQALRSEW

Download         Length: 219 bp

>AT124888 NZ_CP040078:c2061493-2061275 [Burkholderia sp. DHOD12]
ATGAGCCGAGTTTTGGTCGACATCCCCGATACGCAGCTCGAAGCGCTCGCGGCAATCGTGGAGGAAGAGCAACGCCCTCG
CGCCGCGCTCATTCGCGACGCGATCGAGGCCTATATAGCGGATCACAAGCGCTTGCGCGGCGCCGACGTCTTCGGCCTGT
GGAAGAGCAAGAAAATCGACGGCCTCGAATACCAACAGGCGTTGCGCTCGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References