Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 480279..480935 Replicon chromosome
Accession NZ_CP040078
Organism Burkholderia sp. DHOD12

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FAZ95_RS24185 Protein ID WP_137335056.1
Coordinates 480753..480935 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FAZ95_RS24180 Protein ID WP_137335055.1
Coordinates 480279..480698 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAZ95_RS39455 475566..475706 + 141 WP_175425737.1 hypothetical protein -
FAZ95_RS24155 475843..476712 - 870 WP_137335050.1 DMT family transporter -
FAZ95_RS24160 477179..477502 + 324 WP_137335051.1 thioredoxin family protein -
FAZ95_RS24165 477575..478069 + 495 WP_137335052.1 cupin domain-containing protein -
FAZ95_RS24170 478167..478439 - 273 WP_137335053.1 hypothetical protein -
FAZ95_RS24175 478691..480196 + 1506 WP_137335054.1 PQQ-binding-like beta-propeller repeat protein -
FAZ95_RS24180 480279..480698 - 420 WP_137335055.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FAZ95_RS24185 480753..480935 - 183 WP_137335056.1 type II toxin-antitoxin system HicA family toxin Toxin
FAZ95_RS39460 481366..481539 + 174 WP_175425738.1 hypothetical protein -
FAZ95_RS24190 481550..484810 - 3261 WP_137335057.1 autotransporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6678.84 Da        Isoelectric Point: 11.7334

>T124885 WP_137335056.1 NZ_CP040078:c480935-480753 [Burkholderia sp. DHOD12]
MNSSKLIRMLEDDGWKRVRVTGSHHHFKHAGRRGLVTVPHPKKDLPVGTVKSILKAAGLN

Download         Length: 183 bp

>T124885 NZ_CP040078:c480935-480753 [Burkholderia sp. DHOD12]
ATGAATTCATCGAAACTCATCCGCATGCTCGAGGACGACGGCTGGAAACGGGTGAGGGTGACCGGTAGCCATCATCACTT
CAAACACGCCGGCAGACGCGGTTTGGTGACGGTTCCGCACCCCAAGAAAGATCTGCCTGTCGGCACCGTCAAGAGCATTT
TGAAAGCAGCCGGTCTCAACTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15061.10 Da        Isoelectric Point: 4.8029

>AT124885 WP_137335055.1 NZ_CP040078:c480698-480279 [Burkholderia sp. DHOD12]
MDFPIAIHRDEGSVYGVIVPDIPGCHSWGDTLDDAIRNAKEAIVGHVSTLLELGEDVGFTCSTVEELAGKPEFAGVVWAL
VDVDLSKLDSKPERINISIPRFVLRRIDAYVEGRHETRSGFLARAALEALAHAAKPQAA

Download         Length: 420 bp

>AT124885 NZ_CP040078:c480698-480279 [Burkholderia sp. DHOD12]
ATGGATTTCCCGATCGCCATCCATCGAGACGAAGGAAGCGTCTACGGCGTCATCGTTCCCGATATCCCCGGTTGCCATTC
GTGGGGCGATACGCTCGACGATGCAATCAGGAATGCAAAGGAAGCAATAGTCGGCCACGTTTCGACCTTGCTGGAACTCG
GCGAAGACGTCGGGTTCACGTGCTCGACGGTCGAGGAATTGGCAGGAAAGCCCGAATTTGCGGGCGTAGTTTGGGCACTC
GTCGACGTCGATTTATCGAAGCTCGATTCAAAGCCCGAGCGCATCAATATCAGCATCCCGCGGTTTGTTCTGCGCAGGAT
CGACGCCTACGTCGAAGGCCGTCACGAAACGCGTAGCGGATTTTTGGCAAGGGCGGCACTGGAAGCGTTGGCCCACGCCG
CGAAGCCACAGGCCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References