Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3850204..3851927 Replicon chromosome
Accession NZ_CP040077
Organism Burkholderia sp. DHOD12

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FAZ95_RS17655 Protein ID WP_137333626.1
Coordinates 3850569..3851927 (+) Length 453 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FAZ95_RS17650 Protein ID WP_137333625.1
Coordinates 3850204..3850569 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FAZ95_RS17630 3845974..3846954 + 981 WP_137334613.1 proline/glycine betaine ABC transporter permease -
FAZ95_RS17635 3847027..3847848 + 822 WP_137333623.1 betaine/proline/choline family ABC transporter ATP-binding protein -
FAZ95_RS17640 3848054..3849148 - 1095 WP_137333624.1 type 1 fimbrial protein -
FAZ95_RS17645 3849677..3849994 - 318 WP_175425699.1 rubredoxin -
FAZ95_RS17650 3850204..3850569 + 366 WP_137333625.1 helix-turn-helix domain-containing protein Antitoxin
FAZ95_RS17655 3850569..3851927 + 1359 WP_137333626.1 type II toxin-antitoxin system HipA family toxin Toxin
FAZ95_RS17660 3851954..3853207 - 1254 WP_137333627.1 MFS transporter -
FAZ95_RS17665 3853215..3854243 - 1029 WP_137333628.1 aldo/keto reductase -
FAZ95_RS17670 3854374..3855444 - 1071 WP_137334615.1 hypothetical protein -
FAZ95_RS17675 3855709..3856440 - 732 WP_175425700.1 outer membrane lipoprotein-sorting protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(157-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 453 a.a.        Molecular weight: 50042.08 Da        Isoelectric Point: 7.8144

>T124884 WP_137333626.1 NZ_CP040077:3850569-3851927 [Burkholderia sp. DHOD12]
MSRRTQTRRLNVWMNGIPVGYWESARDGERLGYFDEWLADEQGRPLSLSLPFAPGNPPYRGDLVTAFFDNLLPDSDAIRR
RLAQRHHTGSTKPFDLLSALGRDCVGAIQLLPPNEAPTDLREIKGERLTEPDIAQLLRNTTATAPLGLHDRDDDLRLSIA
GAQEKTALLRRDQQWIKPAGSTPTTHIFKLPLGLVGNMQADMRSSIENEWLCSKIVAAYGLPIANCEMANFEDQKVLVVE
RFDRKPASDKKWIVRLPQEDMCQATGTPPLLKYQQDGGPGIAAIMDVLLGSEQAREDRRNFFKTQLVFWLLAATDGHAKN
FSLFHLPGGLYRATPLYDVLSAHPIIGRRRNQIAPQKAKLAMAVRGSSNHYQIDKILPRHWFQQGRQAGLGEAAVQDIIA
EVVDRTESVIDVANDGLPPSFPAAVADAILSGLKKQSGKLAALMTYGAGSET

Download         Length: 1359 bp

>T124884 NZ_CP040077:3850569-3851927 [Burkholderia sp. DHOD12]
ATGAGCCGCCGCACGCAGACACGAAGACTCAACGTATGGATGAACGGCATCCCGGTGGGTTACTGGGAAAGCGCGCGGGA
CGGCGAGCGTCTCGGCTACTTCGATGAATGGCTCGCCGATGAGCAAGGTCGTCCGCTTTCTCTTTCGCTGCCATTCGCGC
CAGGCAACCCGCCTTATCGCGGCGATCTCGTCACCGCGTTTTTCGACAATTTGCTCCCTGATAGCGATGCCATCCGCAGA
CGCCTGGCGCAACGTCACCACACGGGAAGCACGAAGCCGTTCGATCTGTTGTCCGCCCTGGGCCGGGACTGTGTCGGCGC
GATTCAACTGCTCCCGCCGAACGAAGCGCCCACCGATCTCCGCGAAATCAAGGGAGAGCGGCTGACCGAACCGGACATCG
CTCAGCTGCTGCGCAACACAACCGCGACGGCACCGCTTGGCTTGCACGATCGCGATGACGATTTGAGGCTATCGATCGCG
GGGGCCCAAGAAAAAACCGCCTTGTTGCGCCGCGATCAGCAATGGATCAAGCCGGCCGGCAGCACGCCGACCACGCATAT
CTTCAAGCTGCCGCTGGGCCTCGTCGGCAATATGCAGGCCGACATGCGCAGCTCGATCGAAAACGAATGGCTGTGCTCGA
AAATCGTTGCAGCCTACGGGCTACCTATCGCGAACTGCGAGATGGCCAACTTCGAGGATCAGAAGGTGCTCGTCGTCGAG
CGCTTCGATCGTAAGCCGGCGAGCGACAAGAAGTGGATAGTCCGCCTGCCGCAAGAGGACATGTGTCAGGCAACCGGCAC
GCCCCCATTACTCAAGTATCAGCAGGACGGCGGCCCCGGGATCGCCGCGATCATGGACGTGCTGCTCGGCTCAGAACAGG
CGCGCGAGGACAGACGGAATTTCTTCAAGACCCAGCTCGTGTTCTGGCTGCTCGCAGCCACCGACGGGCACGCGAAGAAC
TTCAGCCTCTTCCATTTGCCGGGTGGCCTCTACCGAGCCACGCCGCTTTACGACGTGCTTTCCGCTCACCCGATCATCGG
TCGCCGCCGCAACCAGATCGCGCCGCAAAAAGCGAAACTCGCGATGGCGGTAAGAGGCAGCAGCAACCACTATCAGATCG
ACAAGATCCTGCCGCGACATTGGTTTCAACAAGGGCGGCAGGCCGGGTTGGGCGAGGCCGCGGTGCAGGACATCATCGCC
GAGGTGGTCGATCGGACGGAAAGCGTCATCGACGTTGCGAACGACGGGTTGCCTCCCAGCTTCCCCGCTGCCGTAGCCGA
CGCGATCTTGTCGGGCTTGAAAAAGCAGAGCGGCAAGCTCGCCGCGCTCATGACGTACGGCGCGGGCTCGGAAACCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13142.96 Da        Isoelectric Point: 10.7421

>AT124884 WP_137333625.1 NZ_CP040077:3850204-3850569 [Burkholderia sp. DHOD12]
VDYPIKTLSQLRPILQGFRKAAGLTQAAMASQLGITQQSYAQLEANPAAASMERLFKVMRMLDVEMRLAHEDLPASKAAP
AGTKNDSKQSGTAESSSSARKTPDTNRLRRGGAAPKKREDW

Download         Length: 366 bp

>AT124884 NZ_CP040077:3850204-3850569 [Burkholderia sp. DHOD12]
GTGGACTACCCGATCAAGACACTCAGCCAGCTACGCCCCATTCTTCAAGGTTTTCGCAAGGCCGCCGGCCTCACGCAAGC
CGCCATGGCCAGCCAGTTGGGTATCACGCAGCAGAGCTACGCTCAGCTCGAGGCCAACCCCGCCGCCGCCAGCATGGAAA
GACTCTTCAAAGTCATGCGCATGCTGGATGTCGAAATGCGGCTGGCGCACGAAGATTTACCTGCGAGCAAGGCAGCGCCA
GCCGGCACCAAGAATGACAGCAAACAGTCCGGTACAGCGGAAAGCTCGAGCAGCGCACGAAAAACGCCTGACACCAACCG
CCTTCGCCGCGGCGGCGCCGCCCCGAAGAAGAGGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References