Detailed information of TA system TA124882

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 371042..371561
• Replicon: chromosome
• Accession: NZ_CP040077
• Organism: Burkholderia sp. DHOD12

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: FAZ95_RS01545
• Protein ID: WP_137330820.1
• Coordinates: 371042..371332 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FAZ95_RS01550
• Protein ID: WP_137330821.1
• Coordinates: 371319..371561 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FAZ95_RS01525	366346..367548	+	1203	WP_137330816.1	branched-chain amino acid ABC transporter substrate-binding protein	-
FAZ95_RS01530	367585..368484	+	900	WP_137330817.1	branched-chain amino acid ABC transporter permease	-
FAZ95_RS01535	368488..370311	+	1824	WP_137330818.1	branched-chain amino acid ABC transporter ATP-binding protein/permease	-
FAZ95_RS01540	370299..371024	+	726	WP_137330819.1	ABC transporter ATP-binding protein	-
FAZ95_RS01545	371042..371332	-	291	WP_137330820.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FAZ95_RS01550	371319..371561	-	243	WP_137330821.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FAZ95_RS01555	371832..375428	-	3597	WP_137330822.1	indolepyruvate ferredoxin oxidoreductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-70)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11243.20 Da
• Isoelectric Point: 10.6782

>T124882 WP_137330820.1 NZ_CP040077:c371332-371042 [Burkholderia sp. DHOD12]
MKTYELKFLPSALKEWERLDRTVREQLKSKLAERLRNPRVESARLRNMPDCYKIKLLALGYRLVYQVDDGTVTVVVIAIG
KRERNAAYSAAFKRLN

Nucleotide

• Length: 291 bp

>T124882 NZ_CP040077:c371332-371042 [Burkholderia sp. DHOD12]
TTGAAGACCTATGAACTGAAGTTCTTGCCGTCCGCGCTAAAAGAGTGGGAACGACTCGACAGAACCGTGCGCGAGCAGCT
CAAGAGCAAGCTCGCCGAGCGGCTCCGGAATCCACGCGTCGAGTCCGCACGCCTACGCAATATGCCGGACTGCTACAAGA
TCAAGTTGCTTGCCCTGGGGTATCGGTTGGTCTATCAGGTGGACGACGGTACGGTCACGGTAGTGGTCATCGCCATTGGG
AAGCGCGAGCGGAATGCGGCGTATAGCGCCGCATTCAAACGGCTCAATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8789.08 Da
• Isoelectric Point: 4.3360

>AT124882 WP_137330821.1 NZ_CP040077:c371561-371319 [Burkholderia sp. DHOD12]
MESILARASIGISELKVNPTAAIEQADGPIAVLNRNKPVAYLIPAREWEAICERLEDFELAEIVRARSGEQAVSVKLEDL

Nucleotide

• Length: 243 bp

>AT124882 NZ_CP040077:c371561-371319 [Burkholderia sp. DHOD12]
ATGGAAAGCATTCTTGCCCGCGCCTCGATAGGCATCAGCGAACTCAAAGTCAACCCGACCGCCGCCATTGAGCAAGCTGA
CGGCCCAATCGCGGTGCTCAACCGCAACAAGCCGGTCGCGTACCTGATTCCCGCCCGCGAGTGGGAAGCGATTTGCGAAA
GACTTGAGGATTTCGAGCTGGCTGAGATCGTCAGGGCGCGCAGCGGCGAACAAGCCGTGAGCGTGAAACTTGAAGACCTA
TGA