Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 64881..65482 Replicon plasmid p_unnamed2
Accession NZ_CP040069
Organism Escherichia coli strain A1_181

Toxin (Protein)


Gene name doc Uniprot ID F4TND7
Locus tag FDP43_RS24970 Protein ID WP_001216030.1
Coordinates 64881..65261 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag FDP43_RS24975 Protein ID WP_001190712.1
Coordinates 65261..65482 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDP43_RS24945 60322..61806 - 1485 WP_032163774.1 hypothetical protein -
FDP43_RS24950 61806..62999 - 1194 WP_000219616.1 hypothetical protein -
FDP43_RS24955 63085..63537 - 453 WP_001326849.1 late promoter-activating protein -
FDP43_RS24960 63626..64669 - 1044 WP_139972934.1 DUF968 domain-containing protein -
FDP43_RS24965 64697..64876 - 180 WP_000113018.1 hypothetical protein -
FDP43_RS24970 64881..65261 - 381 WP_001216030.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FDP43_RS24975 65261..65482 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FDP43_RS24980 65555..65944 - 390 WP_000506726.1 DNA repair protein -
FDP43_RS24985 66068..66319 - 252 WP_046644566.1 DNA polymerase III subunit theta -
FDP43_RS26165 66769..66906 + 138 WP_000123562.1 hypothetical protein -
FDP43_RS24995 66981..67343 - 363 WP_001261544.1 hypothetical protein -
FDP43_RS25000 67340..68272 - 933 WP_077787973.1 hypothetical protein -
FDP43_RS25005 68254..68628 - 375 WP_000988658.1 hypothetical protein -
FDP43_RS25010 68635..68928 - 294 WP_046644560.1 hypothetical protein -
FDP43_RS25015 69107..69340 - 234 WP_000516537.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97582 97582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13601.29 Da        Isoelectric Point: 5.1408

>T124875 WP_001216030.1 NZ_CP040069:c65261-64881 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEDITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T124875 NZ_CP040069:c65261-64881 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGATATCACCGATCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCAGAACTGGCAGACCTTACCGTAGGGGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT124875 WP_001190712.1 NZ_CP040069:c65482-65261 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT124875 NZ_CP040069:c65482-65261 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1W8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References