Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 58217..58788 Replicon plasmid p_unnamed2
Accession NZ_CP040069
Organism Escherichia coli strain A1_181

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag FDP43_RS24925 Protein ID WP_011918375.1
Coordinates 58217..58528 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag FDP43_RS24930 Protein ID WP_011787805.1
Coordinates 58528..58788 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDP43_RS24905 53545..53754 + 210 WP_000874156.1 hypothetical protein -
FDP43_RS24910 53865..54716 + 852 WP_000611664.1 hypothetical protein -
FDP43_RS24915 54749..55075 - 327 WP_139972933.1 phage antirepressor KilAC domain-containing protein -
FDP43_RS24920 55113..58193 - 3081 WP_079390445.1 Tn3 family transposase -
FDP43_RS24925 58217..58528 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDP43_RS24930 58528..58788 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FDP43_RS24935 58938..59744 - 807 Protein_57 ORF6N domain-containing protein -
FDP43_RS24940 59741..60325 - 585 Protein_58 host cell division inhibitor Icd-like protein -
FDP43_RS24945 60322..61806 - 1485 WP_032163774.1 hypothetical protein -
FDP43_RS24950 61806..62999 - 1194 WP_000219616.1 hypothetical protein -
FDP43_RS24955 63085..63537 - 453 WP_001326849.1 late promoter-activating protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97582 97582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T124874 WP_011918375.1 NZ_CP040069:c58528-58217 [Escherichia coli]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T124874 NZ_CP040069:c58528-58217 [Escherichia coli]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT124874 WP_011787805.1 NZ_CP040069:c58788-58528 [Escherichia coli]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT124874 NZ_CP040069:c58788-58528 [Escherichia coli]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References