Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 165794..166365 Replicon plasmid p_unnamed1_KPC2
Accession NZ_CP040068
Organism Escherichia coli strain A1_181

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag FDP43_RS24390 Protein ID WP_011918375.1
Coordinates 165794..166105 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag FDP43_RS24395 Protein ID WP_011787805.1
Coordinates 166105..166365 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDP43_RS24370 160811..161347 + 537 WP_000949433.1 hypothetical protein -
FDP43_RS24375 161350..162360 + 1011 WP_000543934.1 tyrosine-type recombinase/integrase -
FDP43_RS24380 162365..162700 + 336 Protein_194 hypothetical protein -
FDP43_RS24385 162690..165770 - 3081 WP_079390445.1 Tn3 family transposase -
FDP43_RS24390 165794..166105 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDP43_RS24395 166105..166365 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FDP43_RS24400 166490..167191 - 702 Protein_198 Tn3 family transposase -
FDP43_RS24405 167254..167958 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
FDP43_RS26380 168010..168090 + 81 Protein_200 cytochrome oxidase subunit II -
FDP43_RS24415 168116..168262 + 147 WP_000859348.1 DUF2474 domain-containing protein -
FDP43_RS24420 168423..169574 - 1152 WP_007372360.1 iron-containing alcohol dehydrogenase -
FDP43_RS24425 170260..170535 - 276 WP_001141269.1 formaldehyde-responsive transcriptional repressor FrmR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid msr(E) / mph(E) / aph(3')-Ia / blaTEM-1A / blaOXA-9 / blaKPC-2 / formA - 1..210031 210031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T124873 WP_011918375.1 NZ_CP040068:c166105-165794 [Escherichia coli]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T124873 NZ_CP040068:c166105-165794 [Escherichia coli]
ATGCCGGTAACTTATCATTTAACGCCCGATGCACAATCTGATCTGATAGGTATTCACCGCTTTACGTTAGCCCAATGGGG
AACGACTCAGTCGAAGACCTATTTATCAGGACTTAGACAAACGATTCAACTGCTGGCTGAAACACCCACCCTTGGGAAAA
ATAGACCCGAGGTACGCATGAATGTGTTTAGCTTCCCTTATTCAAGTCATGTCATCTATTACATCCAACATGAGCATCAA
TTCGTTGTATTTGGGATCTTACATAAAAGTATGGTTCCACTTGCACATCTCGCGGAGCGGGAAATTATTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT124873 WP_011787805.1 NZ_CP040068:c166365-166105 [Escherichia coli]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT124873 NZ_CP040068:c166365-166105 [Escherichia coli]
ATGAACACTCTTTCAGCCAATGAAGCAAAAATTCACTTTGGAGATTTGTTGCTCAAAGCTCAACAAGCTCCAATCCAAAT
TAATAAAAATGGCAAGCCTGTGGCCGTTGTTATTTCAGCTGATGCATACCAAAGTATCGAGACACTAAAATTACATTTGC
TTCAATCCAAAGCGGTGAAAGCCATAACTGACATCAAAATGGGCAATTTGGTTGATGGTAATACCTTTTTTGATGAGCTG
GCCGCAGGGCAGTATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References