Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4378577..4379621 Replicon chromosome
Accession NZ_CP040067
Organism Escherichia coli strain A1_181

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag FDP43_RS21500 Protein ID WP_000019186.1
Coordinates 4378577..4379125 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag FDP43_RS21505 Protein ID WP_000287252.1
Coordinates 4379148..4379621 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDP43_RS21455 4373966..4374340 - 375 Protein_4146 hypothetical protein -
FDP43_RS21460 4374384..4374584 - 201 WP_000649477.1 helix-turn-helix domain-containing protein -
FDP43_RS21465 4374675..4375349 + 675 WP_000859462.1 LexA family transcriptional repressor -
FDP43_RS21480 4376016..4376378 + 363 WP_000135682.1 hypothetical protein -
FDP43_RS21485 4376444..4377268 + 825 WP_001753751.1 DUF2303 family protein -
FDP43_RS21490 4377485..4378237 + 753 WP_001701368.1 hypothetical protein -
FDP43_RS21495 4378274..4378543 + 270 WP_001093912.1 pyocin activator PrtN family protein -
FDP43_RS21500 4378577..4379125 - 549 WP_000019186.1 hypothetical protein Toxin
FDP43_RS21505 4379148..4379621 - 474 WP_000287252.1 SocA family protein Antitoxin
FDP43_RS21510 4379908..4380030 - 123 WP_001300034.1 hypothetical protein -
FDP43_RS21515 4380393..4381409 - 1017 WP_089455116.1 DUF2713 family protein -
FDP43_RS21525 4381727..4382242 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
FDP43_RS21530 4382284..4382493 - 210 WP_001030593.1 CsbD family protein -
FDP43_RS21535 4382609..4383934 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
FDP43_RS21540 4384007..4384615 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T124871 WP_000019186.1 NZ_CP040067:c4379125-4378577 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T124871 NZ_CP040067:c4379125-4378577 [Escherichia coli]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT124871 WP_000287252.1 NZ_CP040067:c4379621-4379148 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT124871 NZ_CP040067:c4379621-4379148 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References