Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49272..50073 Replicon chromosome
Accession NZ_CP040067
Organism Escherichia coli strain A1_181

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag FDP43_RS00255 Protein ID WP_001094437.1
Coordinates 49272..49649 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag FDP43_RS00260 Protein ID WP_001390338.1
Coordinates 49696..50073 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDP43_RS00225 44629..45552 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
FDP43_RS00230 45663..46847 - 1185 WP_001172877.1 sugar efflux transporter -
FDP43_RS00235 47277..47405 - 129 Protein_47 virulence RhuM family protein -
FDP43_RS00240 47640..48485 - 846 WP_001274561.1 DUF4942 domain-containing protein -
FDP43_RS00245 48570..48767 - 198 WP_000772032.1 DUF957 domain-containing protein -
FDP43_RS00250 48787..49275 - 489 WP_000761716.1 hypothetical protein -
FDP43_RS00255 49272..49649 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
FDP43_RS00260 49696..50073 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FDP43_RS00265 50236..50457 - 222 WP_000692345.1 DUF987 domain-containing protein -
FDP43_RS00270 50520..50996 - 477 WP_001186747.1 RadC family protein -
FDP43_RS00275 51012..51485 - 474 WP_000855059.1 antirestriction protein -
FDP43_RS00285 51827..52644 - 818 Protein_56 DUF932 domain-containing protein -
FDP43_RS00295 52799..52957 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T124849 WP_001094437.1 NZ_CP040067:c49649-49272 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T124849 NZ_CP040067:c49649-49272 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT124849 WP_001390338.1 NZ_CP040067:c50073-49696 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT124849 NZ_CP040067:c50073-49696 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References