Detailed information of TA system TA124848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 1873857..1874386
• Replicon: chromosome
• Accession: NZ_CP040059
• Organism: Coxiella burnetii strain RSA439

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q83AB3
• Locus tag: FDP44_RS10310
• Protein ID: WP_005769718.1
• Coordinates: 1874111..1874386 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q83AB4
• Locus tag: FDP44_RS10305
• Protein ID: WP_005769716.1
• Coordinates: 1873857..1874111 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDP44_RS10265	1868925..1869299	+	375	WP_005769706.1	hypothetical protein	-
FDP44_RS10270	1869344..1870042	+	699	WP_010958581.1	outer membrane beta-barrel protein	-
FDP44_RS10275	1870106..1871047	+	942	WP_005769709.1	S49 family peptidase	-
FDP44_RS10280	1871060..1871935	+	876	WP_010958582.1	symmetrical bis(5'-nucleosyl)-tetraphosphatase	-
FDP44_RS10285	1871911..1872024	+	114	Protein_1911	type II toxin-antitoxin system YoeB family toxin	-
FDP44_RS10290	1872084..1872218	+	135	WP_010958583.1	hypothetical protein	-
FDP44_RS10295	1872379..1873398	+	1020	WP_041952483.1	IS110-like element IS1111A family transposase	-
FDP44_RS10300	1873395..1873667	-	273	WP_010957319.1	hypothetical protein	-
FDP44_RS10305	1873857..1874111	+	255	WP_005769716.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FDP44_RS10310	1874111..1874386	+	276	WP_005769718.1	Txe/YoeB family addiction module toxin	Toxin
FDP44_RS10315	1874359..1874844	-	486	WP_005769725.1	dihydrofolate reductase	-
FDP44_RS10320	1874841..1875644	-	804	WP_010958584.1	epoxyqueuosine reductase QueH	-
FDP44_RS10325	1875840..1876127	+	288	WP_010958585.1	acylphosphatase	-
FDP44_RS10330	1876103..1876657	-	555	WP_005769732.1	D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	-
FDP44_RS10335	1876670..1877614	-	945	WP_010958586.1	methionyl-tRNA formyltransferase	-
FDP44_RS10340	1877802..1878728	+	927	WP_010958587.1	DNA-processing protein DprA	-
FDP44_RS10345	1878725..1879204	+	480	WP_010958588.1	DUF494 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1872379..1873398	1019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11150.86 Da
• Isoelectric Point: 9.6762

>T124848 WP_005769718.1 NZ_CP040059:1874111-1874386 [Coxiella burnetii]
MQISFTPEAWEDYLYWQKFDKKMLRRINELIKDAMHEPFSGKGKPEPLKFELQGYWSRRLDQEHRLVYKVLDDSLMIIAA
RFHYNRLNSKN

Nucleotide

• Length: 276 bp

>T124848 NZ_CP040059:1874111-1874386 [Coxiella burnetii]
ATGCAAATTTCCTTCACGCCCGAAGCCTGGGAAGATTATTTATATTGGCAAAAATTCGACAAAAAAATGCTTCGACGCAT
TAATGAACTCATTAAGGATGCTATGCACGAGCCTTTTTCCGGAAAGGGAAAGCCAGAACCTTTAAAATTTGAATTACAAG
GATATTGGTCAAGACGATTAGATCAAGAACATCGATTGGTCTACAAAGTTTTAGACGATTCGTTAATGATTATCGCCGCA
AGATTTCACTATAATCGCCTTAATTCTAAAAACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9624.25 Da
• Isoelectric Point: 10.4802

>AT124848 WP_005769716.1 NZ_CP040059:1873857-1874111 [Coxiella burnetii]
MNVVTFSELRAQLKKILDLSADQHEPVVVKRPNKETMVILSLRDFEALKETAYLLSNEANAARLRQSIRSLKQGKAQKKK
LMED

Nucleotide

• Length: 255 bp

>AT124848 NZ_CP040059:1873857-1874111 [Coxiella burnetii]
ATGAACGTAGTTACTTTTAGCGAACTCAGGGCGCAACTTAAAAAAATCTTGGATCTTTCCGCCGATCAACACGAACCTGT
CGTCGTTAAACGGCCAAATAAAGAAACCATGGTCATTTTATCTTTACGCGACTTTGAGGCTCTAAAAGAAACAGCTTATC
TCTTAAGTAACGAAGCTAATGCGGCCCGTCTTCGTCAGTCTATCCGCAGCTTAAAACAAGGCAAGGCACAAAAAAAGAAA
TTAATGGAAGATTAA

Structures

Toxin

• AlphaFold DB: Q83AB3

Antitoxin

• AlphaFold DB: Q83AB4