Detailed information of TA system TA124846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 3568398..3568951
• Replicon: chromosome
• Accession: NZ_CP040058
• Organism: Anaerostipes rhamnosivorans strain 1y2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AR1Y2_RS17540
• Protein ID: WP_137330134.1
• Coordinates: 3568398..3568676 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AR1Y2_RS17545
• Protein ID: WP_137330135.1
• Coordinates: 3568673..3568951 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AR1Y2_RS17525	3564594..3566552	-	1959	WP_137330131.1	fructose-specific PTS transporter subunit EIIC	-
AR1Y2_RS17530	3566618..3567520	-	903	WP_137330132.1	1-phosphofructokinase	-
AR1Y2_RS17535	3567517..3568263	-	747	WP_137330133.1	DeoR/GlpR family DNA-binding transcription regulator	-
AR1Y2_RS17540	3568398..3568676	-	279	WP_137330134.1	type II toxin-antitoxin system YafQ family toxin	Toxin
AR1Y2_RS17545	3568673..3568951	-	279	WP_137330135.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AR1Y2_RS17550	3569125..3571173	-	2049	WP_137330136.1	ABC transporter permease	-
AR1Y2_RS17555	3571163..3571930	-	768	WP_137330137.1	ABC transporter ATP-binding protein	-
AR1Y2_RS17560	3572108..3572458	+	351	WP_137330138.1	cupin domain-containing protein	-
AR1Y2_RS17565	3572543..3572758	+	216	WP_137330139.1	hypothetical protein	-
AR1Y2_RS17570	3572832..3573839	-	1008	WP_137330140.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-73)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10756.42 Da
• Isoelectric Point: 8.4852

>T124846 WP_137330134.1 NZ_CP040058:c3568676-3568398 [Anaerostipes rhamnosivorans]
MKYEIKRTTKFKKDYKLAVKRGFDVSKLAHIISMLARGQNLPEEYNDHALSGKWSGHRECHIQSDWLLVYYCLEDILVLT
LARVGTHSDLFD

Nucleotide

• Length: 279 bp

>T124846 NZ_CP040058:c3568676-3568398 [Anaerostipes rhamnosivorans]
ATGAAATATGAGATCAAGAGGACTACCAAATTCAAAAAGGATTATAAACTTGCAGTTAAAAGAGGCTTTGATGTTTCAAA
ACTAGCCCACATTATCTCGATGCTTGCCAGAGGACAAAATCTTCCGGAAGAATACAATGACCACGCCCTGTCAGGAAAAT
GGAGCGGGCACAGAGAGTGCCATATTCAGTCTGACTGGCTGCTGGTGTACTATTGTCTGGAAGATATCTTGGTCCTGACC
TTGGCAAGAGTGGGTACACACAGTGACTTATTTGATTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10079.42 Da
• Isoelectric Point: 4.0533

>AT124846 WP_137330135.1 NZ_CP040058:c3568951-3568673 [Anaerostipes rhamnosivorans]
MAGNTSNVSFSIDSELKEQADLLFTNLGIDMTAAFHIFLRQSVREGGIPFEVTMYPKGRETAAAMCEAEEIAKDPSVEGF
LSMEALMADLDR

Nucleotide

• Length: 279 bp

>AT124846 NZ_CP040058:c3568951-3568673 [Anaerostipes rhamnosivorans]
ATGGCTGGAAATACATCAAACGTAAGTTTTAGCATTGATAGTGAGTTAAAAGAACAGGCAGATCTGTTGTTTACCAATCT
TGGGATTGACATGACAGCAGCGTTTCATATATTTTTGAGGCAGTCCGTGAGAGAAGGGGGAATTCCATTTGAGGTAACAA
TGTATCCAAAAGGCAGGGAGACAGCCGCAGCTATGTGTGAGGCAGAAGAGATCGCCAAAGATCCATCCGTAGAGGGTTTC
CTCTCTATGGAAGCTTTAATGGCTGATCTGGACCGATGA