Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 10424..11012 Replicon plasmid unnamed2
Accession NZ_CP040049
Organism Acinetobacter baumannii strain VB1190

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag FDE89_RS19105 Protein ID WP_000438827.1
Coordinates 10725..11012 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag FDE89_RS19100 Protein ID WP_001983304.1
Coordinates 10424..10738 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDE89_RS19085 5597..6762 + 1166 Protein_7 IS3 family transposase -
FDE89_RS19090 7119..7580 - 462 WP_000761346.1 DIP1984 family protein -
FDE89_RS19095 7885..10296 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
FDE89_RS19100 10424..10738 - 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
FDE89_RS19105 10725..11012 - 288 WP_000438827.1 BrnT family toxin Toxin
FDE89_RS19110 11354..11791 - 438 WP_031985418.1 hypothetical protein -
FDE89_RS19115 11784..13163 - 1380 WP_031985417.1 ATP-binding protein -
FDE89_RS19120 13466..14008 - 543 WP_005174436.1 plasmid replication DNA-binding protein -
FDE89_RS19125 14093..15016 - 924 WP_005174434.1 replication initiation protein RepM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..16479 16479


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T124841 WP_000438827.1 NZ_CP040049:c11012-10725 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T124841 NZ_CP040049:c11012-10725 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT124841 WP_001983304.1 NZ_CP040049:c10738-10424 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT124841 NZ_CP040049:c10738-10424 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References