Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3496437..3497094 Replicon chromosome
Accession NZ_CP040038
Organism Klebsiella pneumoniae strain KPC160125

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FDK27_RS17805 Protein ID WP_002916310.1
Coordinates 3496437..3496847 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FDK27_RS17810 Protein ID WP_002916312.1
Coordinates 3496828..3497094 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDK27_RS17785 3492437..3494170 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
FDK27_RS17790 3494176..3494889 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FDK27_RS17795 3494912..3495808 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FDK27_RS17800 3495909..3496430 + 522 WP_002916308.1 flavodoxin FldB -
FDK27_RS17805 3496437..3496847 - 411 WP_002916310.1 protein YgfX Toxin
FDK27_RS17810 3496828..3497094 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FDK27_RS17815 3497340..3498323 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FDK27_RS17820 3498474..3499133 - 660 WP_002916317.1 hemolysin III family protein -
FDK27_RS17825 3499297..3499608 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
FDK27_RS17830 3499658..3500386 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FDK27_RS17835 3500505..3501938 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T124831 WP_002916310.1 NZ_CP040038:c3496847-3496437 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T124831 NZ_CP040038:c3496847-3496437 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT124831 WP_002916312.1 NZ_CP040038:c3497094-3496828 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT124831 NZ_CP040038:c3497094-3496828 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References