Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4824500..4825016 Replicon chromosome
Accession NZ_CP040028
Organism Klebsiella pneumoniae strain KPC160121

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FDK25_RS24385 Protein ID WP_002886902.1
Coordinates 4824500..4824784 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FDK25_RS24390 Protein ID WP_002886901.1
Coordinates 4824774..4825016 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FDK25_RS24360 4819984..4820292 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
FDK25_RS24365 4820377..4820550 + 174 WP_002886906.1 hypothetical protein -
FDK25_RS24370 4820553..4821296 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FDK25_RS24375 4821653..4823791 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
FDK25_RS24380 4824032..4824496 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FDK25_RS24385 4824500..4824784 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FDK25_RS24390 4824774..4825016 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FDK25_RS24395 4825094..4827004 - 1911 WP_004152270.1 BglG family transcription antiterminator -
FDK25_RS24400 4827027..4828181 - 1155 WP_002886900.1 lactonase family protein -
FDK25_RS24405 4828247..4828987 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T124796 WP_002886902.1 NZ_CP040028:c4824784-4824500 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T124796 NZ_CP040028:c4824784-4824500 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT124796 WP_002886901.1 NZ_CP040028:c4825016-4824774 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT124796 NZ_CP040028:c4825016-4824774 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References