Detailed information of TA system TA124760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 555521..556059
• Replicon: chromosome
• Accession: NZ_CP040022
• Organism: Salinivibrio kushneri strain AL184

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FCN78_RS15590
• Protein ID: WP_077659184.1
• Coordinates: 555521..555820 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A2A4GBH9
• Locus tag: FCN78_RS15595
• Protein ID: WP_069588744.1
• Coordinates: 555817..556059 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCN78_RS15550	550916..551602	+	687	WP_077521783.1	NYN domain-containing protein	-
FCN78_RS15560	551815..552336	-	522	WP_131825420.1	hypothetical protein	-
FCN78_RS15565	552375..552686	-	312	WP_077659746.1	hypothetical protein	-
FCN78_RS15570	552677..553084	-	408	WP_077659747.1	DUF2971 domain-containing protein	-
FCN78_RS15575	553176..553578	+	403	Protein_483	transposase	-
FCN78_RS15580	553806..554453	-	648	WP_077521789.1	hypothetical protein	-
FCN78_RS15585	554539..554931	-	393	WP_077521791.1	hypothetical protein	-
FCN78_RS15590	555521..555820	-	300	WP_077659184.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FCN78_RS15595	555817..556059	-	243	WP_069588744.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FCN78_RS15600	556222..557103	-	882	WP_077659185.1	metal ABC transporter permease	-
FCN78_RS15605	557100..557945	-	846	WP_077659186.1	metal ABC transporter permease	-
FCN78_RS15610	557942..558823	-	882	WP_077459579.1	ATP-binding cassette domain-containing protein	-
FCN78_RS15615	558810..559712	-	903	WP_077459578.1	metal ABC transporter substrate-binding protein	-
FCN78_RS15620	559904..560611	-	708	WP_158014697.1	HAD-IB family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	553176..553511	335

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11511.45 Da
• Isoelectric Point: 10.7767

>T124760 WP_077659184.1 NZ_CP040022:c555820-555521 [Salinivibrio kushneri]
MKPFTLTIAAKTDLRNIALFTQRRWGKGQRNLYVKRFDDTFWLLAENPDMGKPCDDIRSGYRKFPLGSHIVFYQPKGNHH
IKVVRILHKSMDVNPALGI

Nucleotide

• Length: 300 bp

>T124760 NZ_CP040022:c555820-555521 [Salinivibrio kushneri]
ATGAAGCCATTTACGCTGACTATCGCCGCTAAAACGGACTTAAGGAATATCGCGTTGTTTACCCAACGTCGTTGGGGAAA
GGGACAGCGCAATCTATATGTAAAACGGTTCGATGACACCTTTTGGTTATTAGCTGAAAACCCAGACATGGGGAAACCAT
GTGATGACATCCGATCAGGATATCGTAAATTTCCTCTTGGCAGCCATATTGTTTTTTATCAACCCAAGGGTAATCATCAC
ATTAAAGTCGTTCGAATCCTGCATAAAAGTATGGACGTAAATCCAGCGTTGGGTATTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8988.82 Da
• Isoelectric Point: 4.0530

>AT124760 WP_069588744.1 NZ_CP040022:c556059-555817 [Salinivibrio kushneri]
MAKNTSITLGEHFDGFIASQIETGRYSSTSEVVRAALRLLENQETKLHTLRQLLVEGEQSGDAEYDIDNFIQEIDAEDTQ

Nucleotide

• Length: 243 bp

>AT124760 NZ_CP040022:c556059-555817 [Salinivibrio kushneri]
ATGGCAAAGAATACAAGTATTACCCTAGGTGAACACTTCGATGGATTTATCGCTAGCCAAATCGAAACGGGGCGTTACAG
CTCGACAAGTGAAGTCGTTCGCGCCGCACTGCGTTTACTCGAAAACCAAGAGACAAAACTGCATACACTGCGTCAACTTC
TCGTAGAGGGCGAACAAAGTGGCGATGCTGAGTATGACATCGATAACTTTATCCAAGAAATCGATGCCGAAGATACGCAA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A2A4GBH9