Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 134741..135386 Replicon chromosome
Accession NZ_CP040022
Organism Salinivibrio kushneri strain AL184

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag FCN78_RS13710 Protein ID WP_069363033.1
Coordinates 134988..135386 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FCN78_RS13705 Protein ID WP_077659247.1
Coordinates 134741..134974 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCN78_RS13685 130132..132579 + 2448 WP_077659244.1 DUF2309 domain-containing protein -
FCN78_RS13690 132588..133559 + 972 WP_106407183.1 threonylcarbamoyl-AMP synthase -
FCN78_RS13695 133570..134004 - 435 WP_077659245.1 PaaI family thioesterase -
FCN78_RS13700 133973..134485 - 513 WP_077659246.1 NifB/NifX family molybdenum-iron cluster-binding protein -
FCN78_RS13705 134741..134974 + 234 WP_077659247.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FCN78_RS13710 134988..135386 + 399 WP_069363033.1 type II toxin-antitoxin system VapC family toxin Toxin
FCN78_RS13715 135418..135699 - 282 WP_021023566.1 DUF134 domain-containing protein -
FCN78_RS13720 135828..137276 - 1449 WP_069363035.1 decarboxylating NADP(+)-dependent phosphogluconate dehydrogenase -
FCN78_RS13725 137288..138013 - 726 WP_077659248.1 6-phosphogluconolactonase -
FCN78_RS13730 138010..139512 - 1503 WP_077458389.1 glucose-6-phosphate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14542.95 Da        Isoelectric Point: 8.7410

>T124758 WP_069363033.1 NZ_CP040022:134988-135386 [Salinivibrio kushneri]
MLDTCICSFIMREQPKAVLKKLHTVVGNQHRIVISAITYQEMQYGLLGKKASPKHAVLVDAFLQRIDEILPWDKAAVDAT
TAVKRNLMNKGTPIGGNDTAIAGHAIATGCVLVTNNTREFQRVEGLKLEDWA

Download         Length: 399 bp

>T124758 NZ_CP040022:134988-135386 [Salinivibrio kushneri]
ATGCTTGATACATGTATTTGTTCATTCATTATGAGAGAGCAACCCAAAGCGGTGTTGAAAAAGCTTCACACTGTTGTCGG
CAATCAACATCGCATTGTTATCTCAGCCATTACCTATCAAGAAATGCAATACGGGTTGTTAGGAAAAAAAGCATCACCAA
AACATGCCGTGCTTGTTGATGCTTTTCTTCAGCGAATCGATGAGATTTTACCTTGGGATAAAGCCGCCGTTGACGCGACA
ACTGCAGTTAAGCGCAACCTAATGAATAAAGGCACCCCTATTGGCGGAAACGACACCGCGATTGCCGGTCACGCCATTGC
GACTGGTTGTGTGCTAGTCACAAACAATACGAGGGAGTTTCAGCGTGTTGAAGGACTGAAACTTGAAGATTGGGCTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8995.10 Da        Isoelectric Point: 4.8668

>AT124758 WP_077659247.1 NZ_CP040022:134741-134974 [Salinivibrio kushneri]
MRTISIFKNGKNQAVRLPKDFEFDGVNELEIHKEGDVITLRPARPSWLSFGELEKADSDFITHREELIKDEGRFNFD

Download         Length: 234 bp

>AT124758 NZ_CP040022:134741-134974 [Salinivibrio kushneri]
ATGAGAACAATATCCATTTTCAAAAATGGCAAGAACCAAGCGGTACGCTTGCCAAAGGATTTTGAGTTTGACGGTGTTAA
TGAGCTTGAAATTCATAAAGAGGGGGATGTCATCACCTTACGCCCAGCTCGACCAAGTTGGCTCTCATTTGGCGAGCTCG
AAAAGGCTGATAGTGATTTCATAACCCATCGCGAGGAACTGATCAAAGATGAGGGGCGGTTCAACTTTGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References