Detailed information of TA system TA124751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1303019..1303545
• Replicon: chromosome
• Accession: NZ_CP040018
• Organism: Arthrobacter sp. 24S4-2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FCN77_RS06100
• Protein ID: WP_137321548.1
• Coordinates: 1303219..1303545 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FCN77_RS06095
• Protein ID: WP_137321547.1
• Coordinates: 1303019..1303222 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FCN77_RS06080	1300449..1301105	-	657	WP_137321545.1	DUF4194 domain-containing protein	-
FCN77_RS06085	1301102..1302544	-	1443	WP_175417164.1	DUF3375 domain-containing protein	-
FCN77_RS06090	1302677..1302923	-	247	Protein_1194	HNH endonuclease	-
FCN77_RS06095	1303019..1303222	+	204	WP_137321547.1	antitoxin MazE family protein	Antitoxin
FCN77_RS06100	1303219..1303545	+	327	WP_137321548.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FCN77_RS06105	1303968..1304345	-	378	WP_137321549.1	TfoX/Sxy family protein	-
FCN77_RS06110	1304589..1305389	+	801	WP_137321550.1	FHA domain-containing protein	-
FCN77_RS06115	1305332..1305862	+	531	WP_137321551.1	hypothetical protein	-
FCN77_RS06120	1305981..1306184	+	204	WP_003806113.1	cold-shock protein	-
FCN77_RS06125	1306278..1306886	-	609	WP_137321552.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-103)

Antitoxin

• Antitoxin MazE-like (4-65)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11674.57 Da
• Isoelectric Point: 8.7297

>T124751 WP_137321548.1 NZ_CP040018:1303219-1303545 [Arthrobacter sp. 24S4-2]
VNRGELWTVSGGTYAQKPRPVLIIQDDLFAAAESVTLLPLTSHLTDAPLLRLTVDPGQLTGLEAVSQIMVDKLTTVRRAH
LGQRIGRIDSKTMVAVEQSLAVFLGLGR

Nucleotide

• Length: 327 bp

>T124751 NZ_CP040018:1303219-1303545 [Arthrobacter sp. 24S4-2]
GTGAATCGCGGTGAGCTGTGGACGGTTTCGGGGGGAACATATGCGCAGAAACCCAGGCCAGTACTCATCATCCAGGATGA
CCTGTTTGCGGCCGCGGAATCGGTCACCCTTCTGCCGCTAACGTCCCACTTGACGGATGCCCCGCTGCTGAGGCTGACGG
TTGACCCCGGACAGCTCACCGGCTTGGAGGCAGTCAGCCAGATCATGGTGGACAAGCTCACAACAGTGCGGCGTGCCCAC
CTCGGGCAGCGGATAGGCCGAATAGATTCCAAGACCATGGTTGCCGTTGAGCAGTCCCTTGCCGTCTTTCTTGGCCTGGG
GCGTTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7970.81 Da
• Isoelectric Point: 5.0877

>AT124751 WP_137321547.1 NZ_CP040018:1303019-1303222 [Arthrobacter sp. 24S4-2]
MSVRDRVARHRVAMRERGFRQIQMWVPDTRTEEFRREAQRQALAVAASDHTSDDQDCIDQIAEDWPE

Nucleotide

• Length: 204 bp

>AT124751 NZ_CP040018:1303019-1303222 [Arthrobacter sp. 24S4-2]
ATGAGCGTAAGGGATCGTGTAGCACGGCACCGAGTTGCCATGCGCGAGCGAGGCTTCCGGCAGATTCAGATGTGGGTTCC
GGACACACGCACAGAGGAGTTCAGGCGTGAAGCCCAGCGGCAAGCGTTGGCGGTCGCGGCCTCCGACCACACCAGCGACG
ATCAAGATTGCATCGACCAGATTGCGGAAGACTGGCCGGAGTGA