Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 927519..929269 Replicon chromosome
Accession NZ_CP040017
Organism Massilia umbonata strain DSMZ 26121

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag FCL38_RS03835 Protein ID WP_137312534.1
Coordinates 927519..928394 (+) Length 292 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag FCL38_RS03840 Protein ID WP_137312535.1
Coordinates 928433..929269 (+) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FCL38_RS03810 923481..924269 + 789 WP_137312530.1 ABC transporter ATP-binding protein -
FCL38_RS03815 924322..925299 + 978 WP_137317253.1 ABC transporter substrate-binding protein -
FCL38_RS03820 925296..926135 + 840 WP_137312531.1 ABC transporter permease -
FCL38_RS03825 926146..926910 + 765 WP_137312532.1 SDR family oxidoreductase -
FCL38_RS03830 926926..927465 + 540 WP_137312533.1 cupin domain-containing protein -
FCL38_RS03835 927519..928394 + 876 WP_137312534.1 alpha/beta hydrolase Toxin
FCL38_RS03840 928433..929269 + 837 WP_137312535.1 IclR family transcriptional regulator Antitoxin
FCL38_RS03845 929280..930080 + 801 WP_137312536.1 SDR family oxidoreductase -
FCL38_RS03850 930073..931809 + 1737 WP_175424699.1 thiamine pyrophosphate-binding protein -
FCL38_RS03855 931819..932619 + 801 WP_137312538.1 aspartate dehydrogenase -
FCL38_RS03860 932630..934114 + 1485 WP_137317254.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-286)

Antitoxin

Transcription regulator IclR, N-terminal

(21-70)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 29844.97 Da        Isoelectric Point: 7.7850

>T124750 WP_137312534.1 NZ_CP040017:927519-928394 [Massilia umbonata]
MPNDAPGSRAEPDGLQAALAELATRFPERTIATEGGTVSYREAGAAGGPTFLLLHGIGSGAASWLDCALELARHGRVIAW
NAPGYGRSAALASAQPGAGAYALRLRQLVQALELDGVTLAGHSLGAMMAAAYAAGHPARLQRLVLLSPARGYGLPARLAQ
GAGVLRDRLSTLGELGIPGMATQRSARLLSPGATATQRDWVRWNMAQLHPGGYTQAVHLLCGDAIENYAQPALAALPAAV
LCGSEDTVTTPEDSRAVAGLFGFPYAPVAGAGHACYVEQPAAVARAILGSR

Download         Length: 876 bp

>T124750 NZ_CP040017:927519-928394 [Massilia umbonata]
ATGCCAAACGACGCCCCAGGCAGCCGTGCCGAGCCCGATGGCCTGCAGGCCGCGCTGGCCGAACTGGCCACGCGCTTCCC
GGAGCGCACGATCGCCACCGAAGGGGGCACCGTGTCGTACCGCGAAGCGGGTGCCGCCGGCGGTCCCACCTTCCTGCTGT
TGCACGGCATCGGGTCGGGCGCCGCCTCCTGGCTGGACTGCGCGCTGGAACTGGCGCGCCACGGCCGGGTGATCGCCTGG
AACGCGCCGGGCTATGGCAGGTCGGCGGCATTGGCCAGCGCGCAGCCCGGCGCCGGCGCCTATGCGCTGCGGCTGCGGCA
ACTGGTGCAGGCGCTGGAACTGGACGGCGTGACGCTGGCCGGGCATTCGCTCGGCGCAATGATGGCGGCGGCCTATGCGG
CTGGACACCCGGCGCGGCTGCAGCGCCTGGTCCTGCTCAGTCCCGCCCGCGGCTACGGCCTGCCGGCACGGCTGGCGCAG
GGCGCCGGGGTGCTGCGCGACCGGCTGTCGACGCTGGGCGAACTGGGCATCCCCGGCATGGCCACGCAGCGCTCGGCACG
GCTGCTGTCGCCGGGCGCCACGGCCACCCAGCGCGACTGGGTACGCTGGAACATGGCGCAGCTGCATCCGGGCGGCTACA
CGCAGGCGGTGCACCTGCTGTGCGGCGATGCGATCGAAAACTATGCGCAGCCCGCGCTGGCCGCGCTGCCGGCCGCCGTG
CTGTGCGGCAGCGAGGATACGGTGACGACGCCGGAGGACAGCCGCGCGGTTGCCGGGCTGTTCGGATTTCCGTATGCGCC
GGTCGCCGGCGCCGGCCATGCCTGCTATGTCGAACAGCCCGCGGCCGTGGCGCGGGCGATCCTGGGCAGCCGATAA

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 31157.54 Da        Isoelectric Point: 6.3970

>AT124750 WP_137312535.1 NZ_CP040017:928433-929269 [Massilia umbonata]
MSNKPEQPDDDGADKYTVPGLERGLRLLCEFSRHDKNLSAPELAKRLDVPRSTVFRLLTTLERMGFVERNEGGRDYRLGM
AVLRLGFEYLASLELTEIGRPLLERLREEIGYSTNIVVRDGRSIVYVAKSSMPAAFVSSVNVGTRLPAHATVLGRVLLQD
MTLPQLREIYPEEHLKVYSENTPQTVLDLFNLVQRDRERGYVLEEGFFERGISTMAAPVRDHSGKVVAALGATIPEPHID
ASRLDSIVGHVRSAAEELSRLLDHVPANSAQVVNLWQR

Download         Length: 837 bp

>AT124750 NZ_CP040017:928433-929269 [Massilia umbonata]
ATGAGCAACAAGCCTGAACAGCCTGACGACGACGGCGCCGACAAGTACACGGTGCCGGGCCTGGAACGGGGCCTGCGCCT
GCTGTGCGAATTCTCCCGCCACGACAAGAACCTGTCGGCCCCGGAGCTGGCCAAGCGCCTCGACGTGCCGCGTTCCACCG
TGTTCCGCCTGCTGACGACCTTGGAACGGATGGGCTTCGTCGAGCGCAACGAGGGTGGCCGCGACTACCGCCTCGGCATG
GCCGTGCTGCGCCTCGGTTTCGAATACCTCGCGTCGCTGGAACTGACCGAGATCGGCCGCCCGCTGCTGGAGCGGCTGCG
CGAGGAAATCGGCTACTCCACCAATATCGTCGTGCGCGACGGCCGCTCGATCGTGTACGTGGCCAAATCTTCCATGCCGG
CGGCATTCGTCAGCAGCGTCAATGTCGGCACGCGCCTGCCGGCCCATGCCACGGTGCTGGGCCGCGTGCTGCTGCAGGAC
ATGACGCTGCCGCAATTGCGCGAGATCTACCCGGAAGAGCACCTGAAGGTGTATTCGGAAAACACGCCGCAGACGGTGCT
GGACCTGTTCAACCTGGTGCAGCGCGACCGCGAGCGCGGCTACGTGCTGGAAGAAGGCTTCTTCGAGCGGGGCATTTCCA
CGATGGCGGCGCCGGTGCGCGACCACAGCGGCAAGGTCGTCGCCGCGCTGGGCGCCACGATCCCGGAACCGCATATCGAT
GCGTCGCGCCTGGATTCGATCGTCGGCCACGTGCGCTCGGCCGCCGAAGAACTGTCCCGGCTGCTGGACCATGTGCCGGC
CAATTCCGCCCAGGTCGTGAACCTGTGGCAGCGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References