Detailed information of TA system TA124745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2489362..2490005
• Replicon: chromosome
• Accession: NZ_CP040007
• Organism: Arachnia propionica strain F0700

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A4P8ZRW0
• Locus tag: FBF34_RS11180
• Protein ID: WP_014847290.1
• Coordinates: 2489604..2490005 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A4P8ZS27
• Locus tag: FBF34_RS11175
• Protein ID: WP_014847289.1
• Coordinates: 2489362..2489607 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FBF34_RS11145	2485206..2486174	-	969	WP_014847283.1	WYL domain-containing protein	-
FBF34_RS11150	2486273..2486656	+	384	WP_014847284.1	VOC family protein	-
FBF34_RS11155	2486762..2488057	+	1296	WP_051015025.1	DUF4143 domain-containing protein	-
FBF34_RS11160	2488429..2488596	-	168	WP_014847286.1	50S ribosomal protein L33	-
FBF34_RS11165	2488598..2488834	-	237	WP_014847287.1	50S ribosomal protein L28	-
FBF34_RS11170	2488919..2489167	+	249	WP_041697718.1	type B 50S ribosomal protein L31	-
FBF34_RS11175	2489362..2489607	+	246	WP_014847289.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FBF34_RS11180	2489604..2490005	+	402	WP_014847290.1	type II toxin-antitoxin system VapC family toxin	Toxin
FBF34_RS11185	2490091..2490789	-	699	WP_014847291.1	50S ribosomal protein L1	-
FBF34_RS11190	2490873..2491301	-	429	WP_014847292.1	50S ribosomal protein L11	-
FBF34_RS11195	2491398..2492183	-	786	WP_014847293.1	transcription termination/antitermination protein NusG	-
FBF34_RS11200	2492180..2492764	-	585	WP_081490305.1	preprotein translocase subunit SecE	-
FBF34_RS11210	2492901..2493923	-	1023	WP_014847295.1	UDP-N-acetylmuramate dehydrogenase	-
FBF34_RS11215	2493916..2494329	-	414	WP_014847296.1	MaoC family dehydratase	-
FBF34_RS11220	2494322..2494750	-	429	WP_014847297.1	MaoC family dehydratase N-terminal domain-containing protein	-
FBF34_RS11225	2494821..2494991	-	171	WP_014847298.1	50S ribosomal protein L33	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (2-76)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 13978.00 Da
• Isoelectric Point: 5.6079

>T124745 WP_014847290.1 NZ_CP040007:2489604-2490005 [Arachnia propionica]
MIVDPSAIAAILLKEPESSGFRELLGRRGGQLSAPGYLELSIVLTARGVTDPVATLDAILLGLGVEVVPFTPSQARLAQE
AHLRFGRGSGHPARLNFGDCISYALAKDTGEPLLFKGNDFVHTDLNPASGISP

Nucleotide

• Length: 402 bp

>T124745 NZ_CP040007:2489604-2490005 [Arachnia propionica]
ATGATCGTCGACCCGTCTGCGATTGCCGCCATCCTGCTGAAGGAGCCGGAGAGCAGCGGCTTCCGTGAGCTGCTGGGCAG
GCGTGGCGGCCAATTGTCCGCCCCCGGTTACCTGGAGTTGTCGATCGTGCTCACGGCGCGGGGAGTCACCGACCCCGTCG
CCACCCTCGATGCGATCCTGCTCGGCCTCGGCGTGGAGGTGGTGCCTTTCACGCCGTCACAGGCTCGCCTGGCTCAGGAG
GCCCACCTGCGTTTCGGCAGGGGCAGCGGCCATCCGGCCAGGCTGAACTTCGGTGACTGCATCAGCTACGCCCTCGCCAA
GGACACCGGGGAACCCCTTTTGTTCAAGGGAAACGACTTCGTCCACACCGATCTGAACCCCGCCTCCGGGATCTCACCCT
GA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8705.75 Da
• Isoelectric Point: 4.5816

>AT124745 WP_014847289.1 NZ_CP040007:2489362-2489607 [Arachnia propionica]
VSLNIKDEHIHDLVRRAATRTGLSQTRVVERAVVELLASLEAEAAASGLDQLLDRVHAELTASGGALDFDALYDPETGLP
R

Nucleotide

• Length: 246 bp

>AT124745 NZ_CP040007:2489362-2489607 [Arachnia propionica]
GTGAGTTTGAACATCAAGGACGAGCACATCCACGACCTGGTCCGTCGGGCCGCCACCCGGACGGGGCTGAGTCAGACCCG
CGTGGTCGAACGGGCCGTGGTTGAGCTGCTGGCCTCCCTGGAAGCGGAAGCCGCCGCCTCCGGTCTCGATCAGCTCCTGG
ACCGGGTGCATGCCGAGCTCACGGCCTCCGGCGGCGCCCTGGACTTCGACGCCCTCTACGACCCCGAGACGGGGTTGCCG
CGATGA

Structures

Toxin

• AlphaFold DB: A0A4P8ZRW0

Antitoxin

• AlphaFold DB: A0A4P8ZS27