Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1798116..1798678 Replicon chromosome
Accession NZ_CP040006
Organism Schaalia odontolytica strain XH001

Toxin (Protein)


Gene name vapC Uniprot ID A0A0V8RXT2
Locus tag FBF35_RS08015 Protein ID WP_060565681.1
Coordinates 1798116..1798487 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0V8S055
Locus tag FBF35_RS08020 Protein ID WP_060566396.1
Coordinates 1798484..1798678 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF35_RS07990 1793310..1794281 - 972 WP_060566395.1 EcsC family protein -
FBF35_RS07995 1794702..1795445 + 744 WP_131726607.1 hypothetical protein -
FBF35_RS08000 1795541..1796218 - 678 WP_131726628.1 hypothetical protein -
FBF35_RS08005 1797064..1797396 - 333 WP_082632802.1 type II toxin-antitoxin system RelE/ParE family toxin -
FBF35_RS08010 1797320..1797856 - 537 WP_060565680.1 hypothetical protein -
FBF35_RS08015 1798116..1798487 - 372 WP_060565681.1 type II toxin-antitoxin system VapC family toxin Toxin
FBF35_RS08020 1798484..1798678 - 195 WP_060566396.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FBF35_RS08030 1799611..1800465 - 855 WP_016456425.1 23S ribosomal RNA methyltransferase Erm -
FBF35_RS08035 1801306..1802682 + 1377 WP_060565682.1 recombinase family protein -
FBF35_RS08040 1802684..1803205 + 522 WP_060565683.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13894.16 Da        Isoelectric Point: 8.0828

>T124742 WP_060565681.1 NZ_CP040006:c1798487-1798116 [Schaalia odontolytica]
VRVLVDTNIWIDHLRKTEPVLVDLLERDQVCVHQSVITELALGNLKNRSVFLKALERLMIVRNVDDQGVRHLVEERRLWG
RGLSAVDVALLASAVVTPGVSLWTRDKRLRQAARDVGVLADLD

Download         Length: 372 bp

>T124742 NZ_CP040006:c1798487-1798116 [Schaalia odontolytica]
GTGAGAGTCCTGGTTGACACCAACATCTGGATCGATCACCTGCGGAAAACTGAGCCGGTTCTGGTTGATCTGCTCGAGCG
TGACCAGGTGTGCGTGCATCAGAGTGTCATCACTGAACTCGCGTTGGGGAATCTCAAGAATCGGTCGGTATTCCTGAAAG
CGCTCGAGCGCTTGATGATCGTGCGCAACGTTGATGATCAAGGCGTGCGGCATCTCGTAGAGGAGCGGAGGCTGTGGGGT
AGGGGACTCAGCGCGGTAGACGTGGCGCTCCTGGCAAGTGCTGTCGTAACCCCCGGTGTCTCGCTGTGGACACGCGATAA
GCGCCTGCGTCAGGCAGCGCGCGACGTGGGCGTGTTAGCGGACCTTGACTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 6807.66 Da        Isoelectric Point: 4.6895

>AT124742 WP_060566396.1 NZ_CP040006:c1798678-1798484 [Schaalia odontolytica]
MRTTVTLDDDLLARAEELTGISERSALIRDAVELLVRIETGRQLAALGGSDSAAEAAPRSRARA

Download         Length: 195 bp

>AT124742 NZ_CP040006:c1798678-1798484 [Schaalia odontolytica]
ATGAGAACCACAGTGACACTCGATGATGATCTGCTTGCGCGCGCCGAGGAGCTGACCGGGATCAGCGAGCGATCCGCTTT
GATTCGGGACGCGGTAGAACTCCTCGTTCGCATCGAGACCGGTCGGCAGCTCGCTGCGCTCGGTGGCAGTGATTCGGCGG
CGGAGGCTGCGCCTCGGAGTCGAGCGCGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V8RXT2

Antitoxin

Source ID Structure
AlphaFold DB A0A0V8S055

References