Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 592694..593244 Replicon chromosome
Accession NZ_CP040006
Organism Schaalia odontolytica strain XH001

Toxin (Protein)


Gene name relE Uniprot ID A0A0V8RSB9
Locus tag FBF35_RS02550 Protein ID WP_060566482.1
Coordinates 592963..593244 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0V8RS16
Locus tag FBF35_RS02545 Protein ID WP_048775138.1
Coordinates 592694..592963 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF35_RS02525 588265..590631 + 2367 WP_060566479.1 hypothetical protein -
FBF35_RS02530 590689..591288 + 600 WP_060566480.1 uracil-DNA glycosylase family protein -
FBF35_RS02535 591328..591768 + 441 WP_060566481.1 aminoacyl-tRNA hydrolase -
FBF35_RS02540 591790..592611 - 822 WP_060567155.1 class I SAM-dependent methyltransferase -
FBF35_RS02545 592694..592963 + 270 WP_048775138.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FBF35_RS02550 592963..593244 + 282 WP_060566482.1 type II toxin-antitoxin system YafQ family toxin Toxin
FBF35_RS02555 593273..594322 + 1050 WP_060566483.1 threonine aldolase -
FBF35_RS02560 594392..595114 + 723 WP_060566484.1 nitroreductase -
FBF35_RS02565 595117..595374 - 258 WP_060566485.1 type II toxin-antitoxin system RelE/ParE family toxin -
FBF35_RS02570 595377..595640 - 264 WP_060566486.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FBF35_RS02575 595793..597115 + 1323 WP_060566487.1 hypothetical protein -
FBF35_RS02580 597117..597722 - 606 WP_060566488.1 methylated-DNA--[protein]-cysteine S-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-86)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10814.55 Da        Isoelectric Point: 9.9974

>T124740 WP_060566482.1 NZ_CP040006:592963-593244 [Schaalia odontolytica]
MTLKVVWTTKFKRDYKRVMKRGLDINRLDQVIRTLAAGEVLAISHRDHALGGDWRGHRECHVQPDWLLIYYVDGERLVLT
LTRTGTHADLFGL

Download         Length: 282 bp

>T124740 NZ_CP040006:592963-593244 [Schaalia odontolytica]
ATGACTCTGAAAGTCGTTTGGACAACGAAGTTTAAGCGCGACTACAAGCGTGTGATGAAGCGCGGGCTCGACATCAATCG
TCTGGATCAAGTTATCCGAACGTTGGCAGCTGGCGAGGTACTCGCTATCTCGCACCGAGATCATGCTCTCGGGGGTGACT
GGCGGGGGCATCGTGAGTGTCATGTTCAGCCTGATTGGCTGCTGATCTATTACGTGGATGGCGAGCGCCTGGTTTTGACC
CTCACGCGGACGGGAACCCACGCAGATCTGTTTGGCCTCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9887.28 Da        Isoelectric Point: 4.1597

>AT124740 WP_048775138.1 NZ_CP040006:592694-592963 [Schaalia odontolytica]
MATVNFSVRMDADLKREVEAIYAELGMNLTSAVNAFLRQSVRVGGMPFDLRLNEQQRETVLAMLEAEQLASDPGVEAMDV
EDALAELKR

Download         Length: 270 bp

>AT124740 NZ_CP040006:592694-592963 [Schaalia odontolytica]
ATGGCAACTGTGAATTTTAGTGTGCGCATGGATGCAGATCTTAAGCGTGAGGTTGAAGCGATCTACGCGGAGCTTGGTAT
GAATCTGACGTCCGCTGTGAACGCTTTCCTCCGTCAGAGCGTGCGGGTGGGTGGAATGCCCTTCGATCTGCGTCTGAATG
AGCAGCAGCGTGAGACTGTCTTGGCGATGTTGGAAGCGGAGCAGCTGGCCTCTGATCCAGGTGTTGAGGCCATGGATGTT
GAAGACGCTCTGGCGGAGTTGAAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V8RSB9

Antitoxin

Source ID Structure
AlphaFold DB A0A0V8RS16

References