Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 264083..264615 Replicon chromosome
Accession NZ_CP040006
Organism Schaalia odontolytica strain XH001

Toxin (Protein)


Gene name relE Uniprot ID A0A0V8RZT5
Locus tag FBF35_RS01175 Protein ID WP_060566227.1
Coordinates 264083..264349 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0V8RZL1
Locus tag FBF35_RS01180 Protein ID WP_060566228.1
Coordinates 264352..264615 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FBF35_RS01170 261450..264050 + 2601 WP_060566226.1 hypothetical protein -
FBF35_RS01175 264083..264349 - 267 WP_060566227.1 Txe/YoeB family addiction module toxin Toxin
FBF35_RS01180 264352..264615 - 264 WP_060566228.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FBF35_RS01185 265082..265507 - 426 WP_060566229.1 YjdF family protein -
FBF35_RS01190 265770..267479 - 1710 WP_060566230.1 ATP-binding cassette domain-containing protein -
FBF35_RS01195 267726..267995 - 270 WP_060566231.1 hypothetical protein -
FBF35_RS01200 268025..269050 - 1026 WP_060566232.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10832.20 Da        Isoelectric Point: 8.0396

>T124739 WP_060566227.1 NZ_CP040006:c264349-264083 [Schaalia odontolytica]
MHITWDEEAWNDYIWWQFEDRKTLKRINALIKDIQRNGNEGIGKPEPLRYEFSGYWSRRIDSRHRLIYQISDDGKALWII
SCRFHYGQ

Download         Length: 267 bp

>T124739 NZ_CP040006:c264349-264083 [Schaalia odontolytica]
ATGCACATCACGTGGGACGAGGAAGCCTGGAACGACTACATCTGGTGGCAGTTCGAGGATCGCAAGACCCTCAAGCGCAT
TAACGCCCTCATCAAGGACATCCAGCGCAACGGGAACGAGGGGATCGGCAAACCTGAACCTCTTCGCTACGAGTTCTCGG
GGTACTGGTCACGCCGAATCGACTCACGGCACCGCCTGATCTACCAGATCAGCGACGACGGCAAAGCCCTCTGGATCATT
TCCTGCCGCTTCCACTACGGCCAGTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10015.26 Da        Isoelectric Point: 4.7064

>AT124739 WP_060566228.1 NZ_CP040006:c264615-264352 [Schaalia odontolytica]
MKTMTYTESRARYAEVLDQVVNDREEIVITRQGHESAVIIALDEYESLMETVYLMQSPANARHLRKSIARHRAGEGVVHD
LIELDED

Download         Length: 264 bp

>AT124739 NZ_CP040006:c264615-264352 [Schaalia odontolytica]
ATGAAGACCATGACCTACACCGAGTCGCGCGCACGCTACGCCGAGGTCCTCGACCAGGTCGTCAACGACCGCGAGGAAAT
CGTCATCACCCGACAGGGCCACGAGAGCGCCGTCATCATCGCCCTCGACGAGTACGAGTCCCTCATGGAGACCGTCTACC
TCATGCAGTCCCCCGCGAACGCCCGCCACCTGCGCAAATCGATCGCACGTCACCGCGCTGGCGAGGGCGTCGTCCATGAC
CTCATTGAGCTCGACGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V8RZT5

Antitoxin

Source ID Structure
AlphaFold DB A0A0V8RZL1

References