Detailed information of TA system TA124738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 447060..447631
• Replicon: chromosome
• Accession: NZ_CP040005
• Organism: Actinomyces sp. oral taxon 171 str. F0337

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: E7N9W2
• Locus tag: FBF36_RS01965
• Protein ID: WP_009395956.1
• Coordinates: 447060..447437 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FBF36_RS01970
• Protein ID: WP_034492080.1
• Coordinates: 447434..447631 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FBF36_RS01950	443054..444901	+	1848	WP_009395950.1	phosphoenolpyruvate carboxykinase (GTP)	-
FBF36_RS01955	445138..446388	+	1251	WP_009395952.1	hypothetical protein	-
FBF36_RS01960	446376..446981	-	606	WP_009395954.1	hypothetical protein	-
FBF36_RS01965	447060..447437	-	378	WP_009395956.1	type II toxin-antitoxin system VapC family toxin	Toxin
FBF36_RS01970	447434..447631	-	198	WP_034492080.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FBF36_RS01975	447840..448667	+	828	WP_009395960.1	AraC family transcriptional regulator	-
FBF36_RS01980	448794..449573	+	780	WP_009395962.1	VOC family protein	-
FBF36_RS01985	449695..452010	-	2316	WP_138137092.1	TerD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-42)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13752.68 Da
• Isoelectric Point: 5.6594

>T124738 WP_009395956.1 NZ_CP040005:c447437-447060 [Actinomyces sp. oral taxon 171 str. F0337]
VILVDTSVWIDHFHHSDPVLVNLLHEDEIGAHPLVVEELAMGSLKARDDVLKHLSHLHQFPTLSHDELLALVATRALWGR
GLSPVDAHLLGSVMLVPGASLWTRDKRLLRAADEHGVSFVEGDDG

Nucleotide

• Length: 378 bp

>T124738 NZ_CP040005:c447437-447060 [Actinomyces sp. oral taxon 171 str. F0337]
GTGATCCTCGTCGACACATCGGTATGGATCGATCACTTCCACCACTCGGATCCAGTACTCGTCAACCTGCTGCACGAGGA
CGAGATCGGGGCCCATCCACTCGTGGTGGAGGAGCTGGCGATGGGTTCACTCAAAGCCAGAGACGACGTCCTCAAGCACT
TGTCGCACCTCCACCAGTTCCCGACCCTCTCACATGACGAGCTGCTGGCTCTGGTCGCAACGCGTGCGCTGTGGGGCCGG
GGCCTCAGCCCCGTCGATGCGCACCTGCTCGGCTCCGTCATGCTGGTCCCTGGCGCCAGCCTGTGGACACGCGACAAGCG
ATTGCTCCGCGCTGCCGACGAGCACGGAGTCTCCTTCGTCGAGGGAGACGACGGCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7018.96 Da
• Isoelectric Point: 11.8674

>AT124738 WP_034492080.1 NZ_CP040005:c447631-447434 [Actinomyces sp. oral taxon 171 str. F0337]
VRTTVTLSDELIANAQELTGITERTELLRAGLETLVRVESARRLAALGGSDRKASAAPRRRSASR

Nucleotide

• Length: 198 bp

>AT124738 NZ_CP040005:c447631-447434 [Actinomyces sp. oral taxon 171 str. F0337]
GTGCGAACCACTGTGACACTCAGCGACGAGCTCATTGCCAACGCTCAGGAGCTCACGGGCATCACTGAGCGCACCGAGCT
GCTGCGCGCCGGCCTGGAGACCCTGGTCAGGGTGGAGAGTGCACGTCGCCTCGCAGCTCTCGGCGGCTCTGATCGGAAGG
CGAGCGCCGCTCCACGACGTCGGAGCGCCAGCCGGTGA

Structures

Toxin

• AlphaFold DB: E7N9W2