Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 842987..843464 Replicon chromosome
Accession NZ_CP039992
Organism Staphylococcus aureus strain Lr3

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag E1E63_RS04190 Protein ID WP_000052076.1
Coordinates 842987..843175 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag E1E63_RS04195 Protein ID WP_001059690.1
Coordinates 843204..843464 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1E63_RS04160 838977..839498 + 522 WP_000824487.1 hypothetical protein -
E1E63_RS04165 839839..840525 + 687 WP_001793574.1 thermonuclease family protein -
E1E63_RS04170 840882..841082 + 201 WP_001059082.1 cold-shock protein -
E1E63_RS04175 841578..841796 - 219 WP_000005886.1 hypothetical protein -
E1E63_RS04180 841858..842142 - 285 WP_001004399.1 hypothetical protein -
E1E63_RS04185 842230..842799 - 570 WP_001106652.1 hypothetical protein -
E1E63_RS04190 842987..843175 - 189 WP_000052076.1 hypothetical protein Toxin
E1E63_RS04195 843204..843464 - 261 WP_001059690.1 hypothetical protein Antitoxin
E1E63_RS04200 843805..844008 + 204 WP_000145164.1 sterile alpha motif-like domain-containing protein -
E1E63_RS04205 844005..844241 - 237 WP_000368687.1 hypothetical protein -
E1E63_RS04210 844466..845047 + 582 WP_001140695.1 phosphoglycerate mutase family protein -
E1E63_RS04215 845120..845737 - 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
E1E63_RS04220 845892..846386 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
E1E63_RS04225 846785..847207 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
E1E63_RS04230 847355..848071 + 717 WP_000150016.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sec / sell / vWbp 809211..853950 44739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T124723 WP_000052076.1 NZ_CP039992:c843175-842987 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T124723 NZ_CP039992:c843175-842987 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT124723 WP_001059690.1 NZ_CP039992:c843464-843204 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT124723 NZ_CP039992:c843464-843204 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References