Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 147608..148524 Replicon plasmid pBT2436
Accession NZ_CP039989
Organism Pseudomonas aeruginosa strain T2436

Toxin (Protein)


Gene name slvT Uniprot ID A0A2I0C753
Locus tag FC629_RS32410 Protein ID WP_058131799.1
Coordinates 147608..148132 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2I0C738
Locus tag FC629_RS32415 Protein ID WP_010792483.1
Coordinates 148129..148524 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC629_RS32390 142929..144074 + 1146 WP_021263240.1 glycerate kinase -
FC629_RS32395 144494..144685 - 192 WP_019437785.1 hypothetical protein -
FC629_RS32400 145060..146115 + 1056 WP_023111115.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
FC629_RS32405 146312..147562 + 1251 WP_128622832.1 TerD family protein -
FC629_RS32410 147608..148132 - 525 WP_058131799.1 RES family NAD+ phosphorylase Toxin
FC629_RS32415 148129..148524 - 396 WP_010792483.1 hypothetical protein Antitoxin
FC629_RS32420 149110..151029 - 1920 WP_079977411.1 helicase -
FC629_RS32425 152340..152864 + 525 WP_010794447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib / floR / tet(G) / ant(4')-IIb / sul1 / qacE / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / ant(2'')-Ia / blaVEB-2 - 1..422811 422811


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19069.61 Da        Isoelectric Point: 4.4540

>T124715 WP_058131799.1 NZ_CP039989:c148132-147608 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWMRP

Download         Length: 525 bp

>T124715 NZ_CP039989:c148132-147608 [Pseudomonas aeruginosa]
ATGAAAATCATCGGAGTGCAGGACCTCCCCTGCTACCGAATGCACACTCCCAAGTGGTCCGTTGCGCCTACATCTGGAGC
TGGAGCTGCAACTCAGGGTGGCCGGGTTAACCGAAAGGGGCTAGAGGCTCTATACCTCTCGCTTGAGTCGGCAACGGCCA
TTGCTGAGTTTCAGCAAGCAAGCGCATTCCTTCCACCAGGTCTGCTGGTCAGCTATTCCCTCAGTCTGGATCGAGTGATC
GACTTCACCGGCGGCTACGACGATACCTGGGCCCCGATCTGGCAAGACTTCTTCTGCGACTGGAGAAAGATTCGCTTCAA
CGACGGCGTTGAACCGCCGAGCTGGATTATCGGGGATCTGGCTATCGAGGCTGACTGTGCTGGGATTCTGTTCGAGTCCG
TTGCGAACCCTGGAGGTCGGAACCTGGTGCTTTTCACCGATCAGTTGCCGGTGCATGGGAATATTGTGGTCAACGATCCT
CGCGGGGATCTCCCTACCGACCAGTCATCTTGGATGCGCCCGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14810.93 Da        Isoelectric Point: 7.2048

>AT124715 WP_010792483.1 NZ_CP039989:c148524-148129 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT124715 NZ_CP039989:c148524-148129 [Pseudomonas aeruginosa]
ATGGCCAGCAAAGCCGTATTAGAGCTTCGCCCCACCAACTTCGCGGGCTTGATGGACGCTCTCAAAGAGGTGAACCGTGT
GATGTTCTCCCCTGAGCGCTTCCTCAAGGTTTTTTCGATGGACCAGCAGACCTTGGCGCTCCGGGCCCATGTCCATCGCA
ACACTGTGCGCAACGCGCCTGAATCGGAAAAGGTCCAGGCCTACATTCGTGATTCAGTGAAGGTTCTGCGTGCAGTGACC
GACATGGGCACGGACGTGACGAATGCCATCTTCTGGTTTAAGAACGAGCCTCTTTCCACGTTCAACTATAAGACCGCGGA
GGAAGTGGTCAGCGAAGGAAAAACCGAGCAGCTGATCGCTTTCCTTCAATCCTGGGAAGCTGGTGCCCAAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I0C753

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0C738

References