Detailed information of TA system TA124710

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 153620..154125
• Replicon: chromosome
• Accession: NZ_CP039988
• Organism: Pseudomonas aeruginosa strain T2436

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: FC629_RS00705
• Protein ID: WP_003083773.1
• Coordinates: 153620..153901 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0H2ZJU8
• Locus tag: FC629_RS00710
• Protein ID: WP_003137009.1
• Coordinates: 153898..154125 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FC629_RS00680	148871..150220	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
FC629_RS00685	150269..150955	+	687	WP_003083762.1	FadR family transcriptional regulator	-
FC629_RS00690	151056..151790	+	735	WP_003128333.1	GntR family transcriptional regulator	-
FC629_RS00695	151994..152380	+	387	WP_196252868.1	aegerolysin family protein	-
FC629_RS00700	152412..153320	-	909	WP_003083769.1	LysR family transcriptional regulator	-
FC629_RS00705	153620..153901	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
FC629_RS00710	153898..154125	-	228	WP_003137009.1	CopG family ribbon-helix-helix protein	Antitoxin
FC629_RS00715	154301..154921	-	621	WP_003101226.1	hypothetical protein	-
FC629_RS00720	155022..155522	+	501	WP_003101228.1	LEA type 2 family protein	-
FC629_RS00725	155595..155936	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
FC629_RS00730	156018..157445	-	1428	WP_003083784.1	GABA permease	-
FC629_RS00735	157614..159107	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T124710 WP_003083773.1 NZ_CP039988:c153901-153620 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T124710 NZ_CP039988:c153901-153620 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8526.56 Da
• Isoelectric Point: 5.5740

>AT124710 WP_003137009.1 NZ_CP039988:c154125-153898 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT124710 NZ_CP039988:c154125-153898 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A0H2ZJU8