Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4892559..4893075 Replicon chromosome
Accession NZ_CP039957
Organism Klebsiella pneumoniae strain EAN23

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FC648_RS24120 Protein ID WP_002886902.1
Coordinates 4892559..4892843 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FC648_RS24125 Protein ID WP_002886901.1
Coordinates 4892833..4893075 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC648_RS24095 4888043..4888351 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
FC648_RS24100 4888436..4888609 + 174 WP_002886906.1 hypothetical protein -
FC648_RS24105 4888612..4889355 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FC648_RS24110 4889712..4891850 + 2139 WP_042943710.1 anaerobic ribonucleoside-triphosphate reductase -
FC648_RS24115 4892091..4892555 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FC648_RS24120 4892559..4892843 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FC648_RS24125 4892833..4893075 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FC648_RS24130 4893153..4895063 - 1911 WP_004152270.1 BglG family transcription antiterminator -
FC648_RS24135 4895086..4896240 - 1155 WP_002886900.1 lactonase family protein -
FC648_RS24140 4896306..4897046 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T124685 WP_002886902.1 NZ_CP039957:c4892843-4892559 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T124685 NZ_CP039957:c4892843-4892559 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT124685 WP_002886901.1 NZ_CP039957:c4893075-4892833 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT124685 NZ_CP039957:c4893075-4892833 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References