Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4797273..4798108 | Replicon | chromosome |
| Accession | NZ_CP039957 | ||
| Organism | Klebsiella pneumoniae strain EAN23 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A5E2RWI0 |
| Locus tag | FC648_RS23730 | Protein ID | WP_001559913.1 |
| Coordinates | 4797273..4797650 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A5E3EVB5 |
| Locus tag | FC648_RS23735 | Protein ID | WP_032408847.1 |
| Coordinates | 4797740..4798108 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FC648_RS23690 | 4792734..4793408 | + | 675 | WP_004152211.1 | hypothetical protein | - |
| FC648_RS23695 | 4793420..4793758 | + | 339 | WP_064449948.1 | hypothetical protein | - |
| FC648_RS23700 | 4793761..4794240 | + | 480 | WP_002887049.1 | type VI secretion system tube protein Hcp | - |
| FC648_RS23705 | 4794432..4794755 | - | 324 | Protein_4650 | superfamily I DNA helicase | - |
| FC648_RS23710 | 4794774..4795885 | - | 1112 | Protein_4651 | IS3 family transposase | - |
| FC648_RS23715 | 4796334..4796486 | - | 153 | WP_164713811.1 | hypothetical protein | - |
| FC648_RS23720 | 4796571..4796858 | - | 288 | WP_073970535.1 | DUF957 domain-containing protein | - |
| FC648_RS23725 | 4796788..4797276 | - | 489 | WP_001559914.1 | hypothetical protein | - |
| FC648_RS23730 | 4797273..4797650 | - | 378 | WP_001559913.1 | TA system toxin CbtA family protein | Toxin |
| FC648_RS23735 | 4797740..4798108 | - | 369 | WP_032408847.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| FC648_RS23740 | 4798285..4798506 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| FC648_RS23745 | 4798575..4799051 | - | 477 | WP_032408846.1 | RadC family protein | - |
| FC648_RS23750 | 4799066..4799551 | - | 486 | WP_088607457.1 | antirestriction protein | - |
| FC648_RS23755 | 4799643..4800461 | - | 819 | WP_001559911.1 | DUF945 domain-containing protein | - |
| FC648_RS23760 | 4800561..4800794 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| FC648_RS23765 | 4800873..4801328 | - | 456 | WP_000581504.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4793761..4816064 | 22303 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14148.10 Da Isoelectric Point: 7.8276
>T124684 WP_001559913.1 NZ_CP039957:c4797650-4797273 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T124684 NZ_CP039957:c4797650-4797273 [Klebsiella pneumoniae]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13682.62 Da Isoelectric Point: 7.8398
>AT124684 WP_032408847.1 NZ_CP039957:c4798108-4797740 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT124684 NZ_CP039957:c4798108-4797740 [Klebsiella pneumoniae]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCATGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCATGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E2RWI0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E3EVB5 |