Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4836645..4837161 Replicon chromosome
Accession NZ_CP039954
Organism Klebsiella pneumoniae strain AR142_2b

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag FC647_RS23445 Protein ID WP_004178374.1
Coordinates 4836645..4836929 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag FC647_RS23450 Protein ID WP_032434351.1
Coordinates 4836919..4837161 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC647_RS23420 4832128..4832436 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
FC647_RS23425 4832521..4832694 + 174 WP_032414379.1 hypothetical protein -
FC647_RS23430 4832697..4833440 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FC647_RS23435 4833797..4835935 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FC647_RS23440 4836177..4836641 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FC647_RS23445 4836645..4836929 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FC647_RS23450 4836919..4837161 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FC647_RS23455 4837239..4839149 - 1911 WP_004152270.1 BglG family transcription antiterminator -
FC647_RS23460 4839172..4840326 - 1155 WP_002886900.1 lactonase family protein -
FC647_RS23465 4840392..4841132 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T124664 WP_004178374.1 NZ_CP039954:c4836929-4836645 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T124664 NZ_CP039954:c4836929-4836645 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT124664 WP_032434351.1 NZ_CP039954:c4837161-4836919 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp

>AT124664 NZ_CP039954:c4837161-4836919 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A6THG1


Antitoxin

Source ID Structure

References