Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 1488797..1489500 Replicon chromosome
Accession NZ_CP039951
Organism Klebsiella pneumoniae strain 18KM2445b

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag FC646_RS07075 Protein ID WP_071994632.1
Coordinates 1488797..1489138 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag FC646_RS07080 Protein ID WP_032434296.1
Coordinates 1489159..1489500 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC646_RS07065 1485112..1485981 + 870 WP_023317468.1 HNH endonuclease -
FC646_RS07070 1486572..1488605 + 2034 WP_050598589.1 hypothetical protein -
FC646_RS07075 1488797..1489138 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
FC646_RS07080 1489159..1489500 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FC646_RS07085 1489511..1490053 - 543 WP_032434298.1 DNA repair protein RadC -
FC646_RS07090 1490066..1490506 - 441 WP_032434300.1 antirestriction protein -
FC646_RS07095 1490537..1491358 - 822 WP_032434301.1 DUF945 domain-containing protein -
FC646_RS07100 1491478..1491951 - 474 WP_032434303.1 hypothetical protein -
FC646_RS07105 1492023..1492475 - 453 WP_032410767.1 hypothetical protein -
FC646_RS07110 1492511..1493227 - 717 WP_032434305.1 WYL domain-containing protein -
FC646_RS07115 1493471..1494345 - 875 Protein_1385 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T124630 WP_071994632.1 NZ_CP039951:c1489138-1488797 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

>T124630 NZ_CP039951:c1489138-1488797 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT124630 WP_032434296.1 NZ_CP039951:c1489500-1489159 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT124630 NZ_CP039951:c1489500-1489159 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References