Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4798479..4799314 Replicon chromosome
Accession NZ_CP039945
Organism Klebsiella pneumoniae strain 19KM28

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5E2RWI0
Locus tag FC644_RS23745 Protein ID WP_001559913.1
Coordinates 4798479..4798856 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5E3EVB5
Locus tag FC644_RS23750 Protein ID WP_032408847.1
Coordinates 4798946..4799314 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC644_RS23705 4793940..4794614 + 675 WP_004152211.1 hypothetical protein -
FC644_RS23710 4794626..4794964 + 339 WP_064449948.1 hypothetical protein -
FC644_RS23715 4794967..4795446 + 480 WP_002887049.1 type VI secretion system tube protein Hcp -
FC644_RS23720 4795638..4795961 - 324 Protein_4652 superfamily I DNA helicase -
FC644_RS23725 4795980..4797091 - 1112 Protein_4653 IS3 family transposase -
FC644_RS23730 4797540..4797692 - 153 WP_164713811.1 hypothetical protein -
FC644_RS23735 4797777..4798064 - 288 WP_073970535.1 DUF957 domain-containing protein -
FC644_RS23740 4797994..4798482 - 489 WP_001559914.1 hypothetical protein -
FC644_RS23745 4798479..4798856 - 378 WP_001559913.1 TA system toxin CbtA family protein Toxin
FC644_RS23750 4798946..4799314 - 369 WP_032408847.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FC644_RS23755 4799491..4799712 - 222 WP_000692300.1 DUF987 domain-containing protein -
FC644_RS23760 4799781..4800257 - 477 WP_032408846.1 RadC family protein -
FC644_RS23765 4800272..4800757 - 486 WP_088607457.1 antirestriction protein -
FC644_RS23770 4800849..4801667 - 819 WP_001559911.1 DUF945 domain-containing protein -
FC644_RS23775 4801767..4802000 - 234 WP_001119729.1 DUF905 family protein -
FC644_RS23780 4802079..4802534 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4794967..4817270 22303


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14148.10 Da        Isoelectric Point: 7.8276

>T124602 WP_001559913.1 NZ_CP039945:c4798856-4798479 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T124602 NZ_CP039945:c4798856-4798479 [Klebsiella pneumoniae]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGACCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTACAGAACGGTAAATAACATTACCCTAGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13682.62 Da        Isoelectric Point: 7.8398

>AT124602 WP_032408847.1 NZ_CP039945:c4799314-4798946 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT124602 NZ_CP039945:c4799314-4798946 [Klebsiella pneumoniae]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCATGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E2RWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A5E3EVB5

References