Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 909131..909788 Replicon chromosome
Accession NZ_CP039939
Organism Klebsiella pneumoniae strain 18KM2517

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FC642_RS04610 Protein ID WP_002916310.1
Coordinates 909378..909788 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FC642_RS04605 Protein ID WP_002916312.1
Coordinates 909131..909397 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC642_RS04580 904287..905720 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
FC642_RS04585 905839..906567 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FC642_RS04590 906617..906928 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
FC642_RS04595 907092..907751 + 660 WP_002916317.1 hemolysin III family protein -
FC642_RS04600 907902..908885 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FC642_RS04605 909131..909397 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FC642_RS04610 909378..909788 + 411 WP_002916310.1 protein YgfX Toxin
FC642_RS04615 909795..910316 - 522 WP_002916308.1 flavodoxin FldB -
FC642_RS04620 910417..911313 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FC642_RS04625 911336..912049 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FC642_RS04630 912055..913788 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T124548 WP_002916310.1 NZ_CP039939:909378-909788 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T124548 NZ_CP039939:909378-909788 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT124548 WP_002916312.1 NZ_CP039939:909131-909397 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT124548 NZ_CP039939:909131-909397 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References