Detailed information of TA system TA124518

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 471420..472073
• Replicon: chromosome
• Accession: NZ_CP039930
• Organism: Acinetobacter baumannii strain TG29392

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: EA667_RS02370
• Protein ID: WP_000607070.1
• Coordinates: 471684..472073 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: EA667_RS02365
• Protein ID: WP_001288210.1
• Coordinates: 471420..471677 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EA667_RS02345	466936..467943	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
EA667_RS02350	467962..468339	+	378	WP_001216380.1	50S ribosomal protein L17	-
EA667_RS02355	468520..470010	+	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
EA667_RS02360	470060..471232	-	1173	WP_001190546.1	acyl-CoA dehydrogenase family protein	-
EA667_RS02365	471420..471677	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
EA667_RS02370	471684..472073	+	390	WP_000607070.1	hypothetical protein	Toxin
EA667_RS02375	472843..473928	+	1086	WP_000049107.1	hypothetical protein	-
EA667_RS02380	474006..474572	+	567	WP_000651536.1	rhombosortase	-
EA667_RS02385	474760..476955	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15708.02 Da
• Isoelectric Point: 10.3599

>T124518 WP_000607070.1 NZ_CP039930:471684-472073 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T124518 NZ_CP039930:471684-472073 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGATCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT124518 WP_001288210.1 NZ_CP039930:471420-471677 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT124518 NZ_CP039930:471420-471677 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7